8qpk: Difference between revisions
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The entry | ==Cryo-EM Structure of Pre-B+5'ss Complex (core part)== | ||
<StructureSection load='8qpk' size='340' side='right'caption='[[8qpk]], [[Resolution|resolution]] 4.20Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8qpk]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8QPK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8QPK FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.2Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IHP:INOSITOL+HEXAKISPHOSPHATE'>IHP</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8qpk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8qpk OCA], [https://pdbe.org/8qpk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8qpk RCSB], [https://www.ebi.ac.uk/pdbsum/8qpk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8qpk ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/PRP6_HUMAN PRP6_HUMAN] Retinitis pigmentosa. The disease may be caused by mutations affecting the gene represented in this entry. Cells from RP60 patients show intron retention for pre-mRNA bearing specific splicing signals. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/PRP6_HUMAN PRP6_HUMAN] Involved in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex, one of the building blocks of the spliceosome. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation.<ref>PMID:12039962</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Dybkov O]] | |||
[[Category: Kastner B]] | |||
[[Category: Kumar V]] | |||
[[Category: Ludwig S]] | |||
[[Category: Luehrmann R]] | |||
[[Category: Stark H]] | |||
[[Category: Urlaub H]] | |||
[[Category: Will CL]] | |||
[[Category: Zhang Z]] | |||
[[Category: Zhong J]] | |||
Revision as of 08:04, 22 May 2024
Cryo-EM Structure of Pre-B+5'ss Complex (core part)
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