8v2n: Difference between revisions

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'''Unreleased structure'''


The entry 8v2n is ON HOLD
==Human SIRT3 co-crystallized with ligands, including p53-AMC peptide and Carba-NAD==
 
<StructureSection load='8v2n' size='340' side='right'caption='[[8v2n]], [[Resolution|resolution]] 1.74&Aring;' scene=''>
Authors: Chakrabarti, R., Ghosh, A., Guan, X., Upadhyay, A., Dumpati, R.K., Munshi, S., Roy, S., Chall, S., Rahnamoun, A., Reverdy, C., Errasti, G., Delacroix, T.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8v2n]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8V2N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8V2N FirstGlance]. <br>
Description: Computationally Driven Discovery and Characterization of SIRT3 Activating Compounds that Fully Recover Catalytic Activity under NAD+ Depletion
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.74&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CNA:CARBA-NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>CNA</scene>, <scene name='pdbligand=FDL:N~6~-ACETYL-N-(4-METHYL-2-OXO-2H-CHROMEN-7-YL)-L-LYSINAMIDE'>FDL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
[[Category: Errasti, G]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8v2n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8v2n OCA], [https://pdbe.org/8v2n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8v2n RCSB], [https://www.ebi.ac.uk/pdbsum/8v2n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8v2n ProSAT]</span></td></tr>
[[Category: Delacroix, T]]
</table>
[[Category: Upadhyay, A]]
== Function ==
[[Category: Chakrabarti, R]]
[https://www.uniprot.org/uniprot/SIR3_HUMAN SIR3_HUMAN] NAD-dependent protein deacetylase. Activates mitochondrial target proteins, including ACSS1, IDH2 and GDH by deacetylating key lysine residues. Contributes to the regulation of the cellular energy metabolism. Important for regulating tissue-specific ATP levels.<ref>PMID:16788062</ref> <ref>PMID:18680753</ref> <ref>PMID:18794531</ref> <ref>PMID:19535340</ref>
[[Category: Ghosh, A]]
== References ==
[[Category: Dumpati, R.K]]
<references/>
[[Category: Guan, X]]
__TOC__
[[Category: Rahnamoun, A]]
</StructureSection>
[[Category: Munshi, S]]
[[Category: Homo sapiens]]
[[Category: Chall, S]]
[[Category: Large Structures]]
[[Category: Roy, S]]
[[Category: Chakrabarti R]]
[[Category: Reverdy, C]]
[[Category: Chall S]]
[[Category: Delacroix T]]
[[Category: Dumpati RK]]
[[Category: Errasti G]]
[[Category: Ghosh A]]
[[Category: Guan X]]
[[Category: Munshi S]]
[[Category: Rahnamoun A]]
[[Category: Reverdy C]]
[[Category: Roy S]]
[[Category: Upadhyay A]]
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