8wg5: Difference between revisions
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==Cryo-EM structure of USP16 bound to H2AK119Ub nucleosome== | |||
<StructureSection load='8wg5' size='340' side='right'caption='[[8wg5]], [[Resolution|resolution]] 3.05Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8wg5]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8WG5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8WG5 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.05Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8wg5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8wg5 OCA], [https://pdbe.org/8wg5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8wg5 RCSB], [https://www.ebi.ac.uk/pdbsum/8wg5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8wg5 ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: | == Disease == | ||
[[Category: He | [https://www.uniprot.org/uniprot/UBP16_HUMAN UBP16_HUMAN] Note=A chromosomal aberration involving USP16 is a cause of Chronic myelomonocytic leukemia. Inversion inv(21) (q21;q22) with RUNX1/AML1. | ||
[[Category: | == Function == | ||
[https://www.uniprot.org/uniprot/UBP16_HUMAN UBP16_HUMAN] Specifically deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-10' of histone H3, and is required for chromosome segregation when cells enter into mitosis. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.<ref>PMID:10077596</ref> <ref>PMID:11753566</ref> <ref>PMID:17914355</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Ai HS]] | |||
[[Category: Deng ZH]] | |||
[[Category: He ZZ]] | |||
[[Category: Liu L]] | |||
Revision as of 23:17, 27 December 2023
Cryo-EM structure of USP16 bound to H2AK119Ub nucleosome
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