1ojl: Difference between revisions

Line 1:

[[Image:1ojl.~~gif~~|left|200px]]

[[Image:1ojl.png|left|200px]]

<!--

Line 9:

Line 10:

~~'''~~CRYSTAL STRUCTURE OF A SIGMA54-ACTIVATOR SUGGESTS THE MECHANISM FOR THE CONFORMATIONAL SWITCH NECESSARY FOR SIGMA54 BINDING~~'''~~

===CRYSTAL STRUCTURE OF A SIGMA54-ACTIVATOR SUGGESTS THE MECHANISM FOR THE CONFORMATIONAL SWITCH NECESSARY FOR SIGMA54 BINDING===

~~==Overview==~~

<!--

The ~~sigma(54)-dependent transcription in bacteria is associated with various stress and growth conditions. Activators of~~ the ~~sigma(54) protein contain a central domain belonging~~ to the ~~AAA+ superfamily of ATPases, members of which function in diverse cellular processes in both prokaryotic and eukaryotic cells~~. ~~We describe the X-ray structure of an N-terminal domain deletion of the ZraR protein from Salmonella typhimurium~~, ~~which~~ is ~~a homologue of~~ the ~~general nitrogen regulatory protein NtrC, at 3A resolution~~. The structure reveals a hexameric ring that is typical for AAA+ containing proteins but which differs from the heptameric ring found in the crystal structure of the AAA+ domain of NtrC1 from Aquifex aeolicus. The dimerisation interface between DNA-~~binding domains observed in the crystal structure suggests that dodecamers, rather than hexamers, might be the functionally important oligomer.~~

The line below this paragraph, {{ABSTRACT_PUBMED_16005641}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 16005641 is the PubMed ID number.

-->

==About this Structure==

Line 30:

Line 34:

[[Category: Transcription regulation]]

[[Category: Two component system]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 03~~:55:45 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 12:37:56 2008''

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-[[Image:1ojl.gif|left|200px]]
+{{Seed}}
+[[Image:1ojl.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_1ojl|  PDB=1ojl  |  SCENE=  }}
-'''CRYSTAL STRUCTURE OF A SIGMA54-ACTIVATOR SUGGESTS THE MECHANISM FOR THE CONFORMATIONAL SWITCH NECESSARY FOR SIGMA54 BINDING'''
+===CRYSTAL STRUCTURE OF A SIGMA54-ACTIVATOR SUGGESTS THE MECHANISM FOR THE CONFORMATIONAL SWITCH NECESSARY FOR SIGMA54 BINDING===
-==Overview==
+<!--
-The sigma(54)-dependent transcription in bacteria is associated with various stress and growth conditions. Activators of the sigma(54) protein contain a central domain belonging to the AAA+ superfamily of ATPases, members of which function in diverse cellular processes in both prokaryotic and eukaryotic cells. We describe the X-ray structure of an N-terminal domain deletion of the ZraR protein from Salmonella typhimurium, which is a homologue of the general nitrogen regulatory protein NtrC, at 3A resolution. The structure reveals a hexameric ring that is typical for AAA+ containing proteins but which differs from the heptameric ring found in the crystal structure of the AAA+ domain of NtrC1 from Aquifex aeolicus. The dimerisation interface between DNA-binding domains observed in the crystal structure suggests that dodecamers, rather than hexamers, might be the functionally important oligomer.
+The line below this paragraph, {{ABSTRACT_PUBMED_16005641}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 16005641 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_16005641}}
 ==About this Structure==
@@ Line 30: / Line 34: @@
 [[Category: Transcription regulation]]
 [[Category: Two component system]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 03:55:45 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 12:37:56 2008''