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| {{STRUCTURE_1omk| PDB=1omk | SCENE= }} | | {{STRUCTURE_1omk| PDB=1omk | SCENE= }} |
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| '''The Crystal Structure of d(CACG(5IU)G)'''
| | ===The Crystal Structure of d(CACG(5IU)G)=== |
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| ==Overview==
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| The first antiviral nucleoside 5-iodo-2'-deoxyuridine (IDU) against herpes simplex virus type 1 and type 2 is a thymidine analogue, i.e. the C5 methyl group is replaced by an I atom. The structure of the self-complementary hexamer d[CACG(IDU)G] was determined by single-crystal X-ray diffraction techniques. The orthorhombic crystals belong to space group P2(1)2(1)2(1), with unit-cell parameters a = 18.16, b = 30.03, c = 41.99 A. Refinement in the resolution range 20-1.3 A converged with a final R1 = 0.167, including 43 water molecules and two cobalt hexammine complexes. The incorporation of a large I atom has only minor consequences for the overall structure as is noticed in the IDU.A base pairs, which are of the common Watson-Crick type. To contribute to the still puzzling mechanism of this historically important agent, details of base stacking, helical parameters, hydration etc. have been studied. A general scheme of cobalt hexammine-binding modes in Z-DNA is provided, revealing similar binding modes for the reported structure. | | The line below this paragraph, {{ABSTRACT_PUBMED_12876373}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 12876373 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_12876373}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: 5-iodo-2'-deoxyuridine]] | | [[Category: 5-iodo-2'-deoxyuridine]] |
| [[Category: Z-dna]] | | [[Category: Z-dna]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:02:01 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 13:38:29 2008'' |
