1oo2: Difference between revisions

Line 1:

[[Image:1oo2.~~gif~~|left|200px]]

[[Image:1oo2.png|left|200px]]

<!--

Line 9:

Line 10:

~~'''~~Crystal structure of transthyretin from Sparus aurata~~'''~~

===Crystal structure of transthyretin from Sparus aurata===

~~==Overview==~~

<!--

~~The thyroid hormone binding protein transthyretin (TTR) forms a macromolecular complex with the retinol~~-~~specific carrier retinol binding protein (RBP) in the blood of higher vertebrates. Piscine TTR is shown here to exhibit high binding affinity for L~~-~~thyroxine and negligible affinity for RBP.~~ The ~~1.56 A resolution X-ray structure of sea bream TTR~~, ~~compared with that of human TTR~~, ~~reveals a high degree of conservation of~~ the ~~thyroid hormone binding sites. In contrast, some amino acid differences in discrete regions of sea bream TTR appear~~ to ~~be responsible for~~ the ~~lack of protein-protein recognition~~, ~~providing evidence for~~ the ~~crucial role played by a limited~~ number ~~of residues in the interaction between RBP and TTR. Overall, this study makes it possible to draw conclusions on evolutionary relationships for RBPs and TTRs of phylogenetically distant vertebrates~~.

The line below this paragraph, {{ABSTRACT_PUBMED_14644428}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 14644428 is the PubMed ID number.

-->

==About this Structure==

Line 31:

Line 35:

[[Category: Tetramer]]

[[Category: Transthyretin]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 04~~:05:16 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:59:26 2008''

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-[[Image:1oo2.gif|left|200px]]
+{{Seed}}
+[[Image:1oo2.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_1oo2|  PDB=1oo2  |  SCENE=  }}
-'''Crystal structure of transthyretin from Sparus aurata'''
+===Crystal structure of transthyretin from Sparus aurata===
-==Overview==
+<!--
-The thyroid hormone binding protein transthyretin (TTR) forms a macromolecular complex with the retinol-specific carrier retinol binding protein (RBP) in the blood of higher vertebrates. Piscine TTR is shown here to exhibit high binding affinity for L-thyroxine and negligible affinity for RBP. The 1.56 A resolution X-ray structure of sea bream TTR, compared with that of human TTR, reveals a high degree of conservation of the thyroid hormone binding sites. In contrast, some amino acid differences in discrete regions of sea bream TTR appear to be responsible for the lack of protein-protein recognition, providing evidence for the crucial role played by a limited number of residues in the interaction between RBP and TTR. Overall, this study makes it possible to draw conclusions on evolutionary relationships for RBPs and TTRs of phylogenetically distant vertebrates.
+The line below this paragraph, {{ABSTRACT_PUBMED_14644428}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 14644428 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_14644428}}
 ==About this Structure==
@@ Line 31: / Line 35: @@
 [[Category: Tetramer]]
 [[Category: Transthyretin]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 04:05:16 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:59:26 2008''