1ook: Difference between revisions

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[[Image:1ook.~~gif~~|left|200px]]

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~~'''~~Crystal Structure of the Complex of Platelet Receptor GPIb-alpha and Human alpha-Thrombin~~'''~~

===Crystal Structure of the Complex of Platelet Receptor GPIb-alpha and Human alpha-Thrombin===

~~==Overview==~~

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~~Thrombin bound to platelets contributes to stop bleeding and~~, ~~in pathological conditions~~, ~~may cause vascular thrombosis. We have determined~~ the ~~structure of platelet glycoprotein Ibalpha~~ (~~GpIbalpha) bound to thrombin~~ at 2.~~3 angstrom resolution and defined two sites in GpIbalpha that bind to exosite II and exosite I of two distinct alpha-thrombin molecules, respectively~~. ~~GpIbalpha occupancy may be sequential~~, ~~as the site binding to alpha-thrombin exosite I appears to be cryptic in~~ the ~~unoccupied receptor but exposed when a first thrombin molecule is bound through exosite II~~. ~~These interactions may modulate alpha~~-~~thrombin function by mediating GpIbalpha clustering and cleavage of protease~~-~~activated receptors, which promote platelet activation, while limiting fibrinogen clotting through blockade of exosite I.~~

The line below this paragraph, {{ABSTRACT_PUBMED_12855810}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 12855810 is the PubMed ID number.

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==Disease==

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[[Category: Varughese, K I.]]

[[Category: Leucine rich repeat]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 04~~:06:17 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:22:54 2008''

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-[[Image:1ook.gif|left|200px]]
+{{Seed}}
+[[Image:1ook.png|left|200px]]
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 {{STRUCTURE_1ook|  PDB=1ook  |  SCENE=  }}
-'''Crystal Structure of the Complex of Platelet Receptor GPIb-alpha and Human alpha-Thrombin'''
+===Crystal Structure of the Complex of Platelet Receptor GPIb-alpha and Human alpha-Thrombin===
-==Overview==
+<!--
-Thrombin bound to platelets contributes to stop bleeding and, in pathological conditions, may cause vascular thrombosis. We have determined the structure of platelet glycoprotein Ibalpha (GpIbalpha) bound to thrombin at 2.3 angstrom resolution and defined two sites in GpIbalpha that bind to exosite II and exosite I of two distinct alpha-thrombin molecules, respectively. GpIbalpha occupancy may be sequential, as the site binding to alpha-thrombin exosite I appears to be cryptic in the unoccupied receptor but exposed when a first thrombin molecule is bound through exosite II. These interactions may modulate alpha-thrombin function by mediating GpIbalpha clustering and cleavage of protease-activated receptors, which promote platelet activation, while limiting fibrinogen clotting through blockade of exosite I.
+The line below this paragraph, {{ABSTRACT_PUBMED_12855810}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 12855810 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_12855810}}
 ==Disease==
@@ Line 30: / Line 34: @@
 [[Category: Varughese, K I.]]
 [[Category: Leucine rich repeat]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 04:06:17 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:22:54 2008''