8unf: Difference between revisions

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'''Unreleased structure'''


The entry 8unf is ON HOLD  until Paper Publication
==Cryo-EM structure of T4 Bacteriophage Clamp Loader with Sliding Clamp and DNA==
 
<StructureSection load='8unf' size='340' side='right'caption='[[8unf]], [[Resolution|resolution]] 3.15&Aring;' scene=''>
Authors: Huang, Y., Marcus, K., Subramanian, S., Gee, L.C., Gorday, K., Ghaffari-Kashani, S., Luo, X., Zhang, L., O''Donnell, M., Subramanian, S., Kuriyan, J.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8unf]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8UNF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8UNF FirstGlance]. <br>
Description: Cryo-EM structure of T4 Bacteriophage Clamp Loader with Sliding Clamp and DNA
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.15&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=08T:[[[(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-BIS(OXIDANYL)OXOLAN-2-YL]METHOXY-OXIDANYL-PHOSPHORYL]OXY-OXIDANYL-PHOSPHORYL]OXY-TRIS(FLUORANYL)BERYLLIUM'>08T</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
[[Category: Gorday, K]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8unf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8unf OCA], [https://pdbe.org/8unf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8unf RCSB], [https://www.ebi.ac.uk/pdbsum/8unf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8unf ProSAT]</span></td></tr>
[[Category: Gee, L.C]]
</table>
[[Category: Subramanian, S]]
== Function ==
[[Category: Kuriyan, J]]
[https://www.uniprot.org/uniprot/CLAMP_BPT4 CLAMP_BPT4] Sliding clamp that encircles the genomic DNA and links the DNA polymerase to the template to control the processivity of DNA synthesis. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication (PubMed:10535942). Interaction with the sliding-clamp-loader opens the sliding clamp so that it can be loaded around the DNA template (PubMed:22194570). During transcription, encircles the DNA and tethers host RNA polymerase (RNAP) to it (PubMed:33602900).[HAMAP-Rule:MF_04161]<ref>PMID:10535942</ref> <ref>PMID:22194570</ref> <ref>PMID:33602900</ref>
[[Category: Ghaffari-Kashani, S]]
== References ==
[[Category: O''Donnell, M]]
<references/>
[[Category: Zhang, L]]
__TOC__
[[Category: Luo, X]]
</StructureSection>
[[Category: Marcus, K]]
[[Category: Escherichia virus T4]]
[[Category: Huang, Y]]
[[Category: Large Structures]]
[[Category: Gee LC]]
[[Category: Ghaffari-Kashani S]]
[[Category: Gorday K]]
[[Category: Huang Y]]
[[Category: Kuriyan J]]
[[Category: Luo X]]
[[Category: Marcus K]]
[[Category: O'Donnell M]]
[[Category: Subramanian S]]
[[Category: Zhang L]]
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