1or6: Difference between revisions

Line 1:

[[Image:1or6.~~gif~~|left|200px]]

[[Image:1or6.png|left|200px]]

<!--

Line 9:

Line 10:

~~'''~~Crystal Structure of HemAT sensor domain from B.subtilis in the unliganded form~~'''~~

===Crystal Structure of HemAT sensor domain from B.subtilis in the unliganded form===

~~==Overview==~~

<!--

~~Much is now known about chemotaxis signaling transduction for Escherichia coli and Salmonella typhimurium.~~ The ~~mechanism of chemotaxis of Bacillus subtilis is, in a sense~~, ~~reversed. Attractant binding strengthens the activity of histidine kinase in B. subtilis~~, ~~instead of an inhibition reaction. The HemAT from B. subtilis can detect oxygen and transmit~~ the ~~signal~~ to ~~regulatory proteins that control~~ the ~~direction of flagella rotation. We have determined the crystal structures of the HemAT sensor domain in liganded and unliganded forms~~ at 2.~~15 A and 2~~.~~7 A resolution~~, respectively. The liganded structure reveals a highly symmetrical organization. Tyrosine70 shows distinct conformational changes on one subunit when ligands are removed. Our study suggests that disruption of the symmetry of HemAT plays an important role in initiating the ~~chemotaxis signaling transduction cascade~~.

The line below this paragraph, {{ABSTRACT_PUBMED_12962628}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 12962628 is the PubMed ID number.

-->

==About this Structure==

Line 25:

Line 29:

[[Category: Zhang, W.]]

[[Category: Globin fold]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 04~~:11:04 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:54:42 2008''

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-[[Image:1or6.gif|left|200px]]
+{{Seed}}
+[[Image:1or6.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_1or6|  PDB=1or6  |  SCENE=  }}
-'''Crystal Structure of HemAT sensor domain from B.subtilis in the unliganded form'''
+===Crystal Structure of HemAT sensor domain from B.subtilis in the unliganded form===
-==Overview==
+<!--
-Much is now known about chemotaxis signaling transduction for Escherichia coli and Salmonella typhimurium. The mechanism of chemotaxis of Bacillus subtilis is, in a sense, reversed. Attractant binding strengthens the activity of histidine kinase in B. subtilis, instead of an inhibition reaction. The HemAT from B. subtilis can detect oxygen and transmit the signal to regulatory proteins that control the direction of flagella rotation. We have determined the crystal structures of the HemAT sensor domain in liganded and unliganded forms at 2.15 A and 2.7 A resolution, respectively. The liganded structure reveals a highly symmetrical organization. Tyrosine70 shows distinct conformational changes on one subunit when ligands are removed. Our study suggests that disruption of the symmetry of HemAT plays an important role in initiating the chemotaxis signaling transduction cascade.
+The line below this paragraph, {{ABSTRACT_PUBMED_12962628}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 12962628 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_12962628}}
 ==About this Structure==
@@ Line 25: / Line 29: @@
 [[Category: Zhang, W.]]
 [[Category: Globin fold]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 04:11:04 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:54:42 2008''