1orc: Difference between revisions

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[[Image:1orc.gif|left|200px]]
{{Seed}}
[[Image:1orc.png|left|200px]]


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{{STRUCTURE_1orc|  PDB=1orc  |  SCENE=  }}  
{{STRUCTURE_1orc|  PDB=1orc  |  SCENE=  }}  


'''CRO REPRESSOR INSERTION MUTANT K56-[DGEVK]'''
===CRO REPRESSOR INSERTION MUTANT K56-[DGEVK]===




==Overview==
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A rationally designed, genetically engineered, monomeric form of the Cro protein from bacteriophage lambda has been crystallized and its structure determined by isomorphous replacement and refined to a resolution of 1.54 A. The structure confirms the rationale of the design but, at the same time, reveals 1-2 A shifts throughout the monomer structure relative to the previously determined structure of the dimeric wild-type protein. These changes include a 1.6 A main-chain shift in part of the beta-sheet region of the molecule relative to the alpha-helical region and a 1.1 A shift of a buried phenylalanine within the core as well as a correlated 2.2 A shift in a solvent-exposed beta-hairpin. The conformational adjustments appear to reflect an inherent flexibility of the protein that is associated with its DNA-binding function.
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{{ABSTRACT_PUBMED_8547253}}


==About this Structure==
==About this Structure==
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[[Category: Mossing, M C.]]
[[Category: Mossing, M C.]]
[[Category: Gene regulating protein]]
[[Category: Gene regulating protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 13:26:25 2008''

Revision as of 10:26, 28 July 2008

File:1orc.png

Template:STRUCTURE 1orc

CRO REPRESSOR INSERTION MUTANT K56-[DGEVK]

Template:ABSTRACT PUBMED 8547253

About this Structure

1ORC is a Single protein structure of sequence from Enterobacteria phage lambda. Full crystallographic information is available from OCA.

Reference

High-resolution structure of an engineered Cro monomer shows changes in conformation relative to the native dimer., Albright RA, Mossing MC, Matthews BW, Biochemistry. 1996 Jan 23;35(3):735-42. PMID:8547253

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