1osr: Difference between revisions

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[[Image:1osr.gif|left|200px]]
{{Seed}}
[[Image:1osr.png|left|200px]]


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{{STRUCTURE_1osr|  PDB=1osr  |  SCENE=  }}  
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'''Structural study of dna duplex containaing a n-(2-deoxy-beta-erytho-pentofuranosyl) formamide frameshift by nmr and restrained molecular dynamics'''
===Structural study of dna duplex containaing a n-(2-deoxy-beta-erytho-pentofuranosyl) formamide frameshift by nmr and restrained molecular dynamics===




==Overview==
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The presence of an N-(2-deoxy-beta-D-erythro-pentofuranosyl) formamide (F) residue, a ring fragmentation product of thymine, in a frameshift context in the sequence 5'-d-(AGGACCACG)*d(CGTGGFTCCT) has been studied by 1H and 31P nuclear magnetic resonance (NMR) and molecular dynamics. Two-dimensional NMR studies show that the formamide residue, whether the cis or trans isomer, is rotated out of the helix and that the bases on either side of the formamide residue in the sequence, G14 and T16, are stacked over each other in a way similar to normal B-DNA. The cis and trans isomers were observed in the ratio 3:2 in solution. Information extracted from 31P NMR data reveal a modification of the phosphodiester backbone conformation at the extrahelical site, which is also observed during the molecular dynamics simulations.
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{{ABSTRACT_PUBMED_14530441}}


==About this Structure==
==About this Structure==
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OSR OCA].  
Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OSR OCA].  


==Reference==
==Reference==
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[[Category: Modified base]]
[[Category: Modified base]]
[[Category: Mutagenesis]]
[[Category: Mutagenesis]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 04:14:19 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 11:22:13 2008''

Revision as of 08:22, 28 July 2008

File:1osr.png

Template:STRUCTURE 1osr

Structural study of dna duplex containaing a n-(2-deoxy-beta-erytho-pentofuranosyl) formamide frameshift by nmr and restrained molecular dynamics

Template:ABSTRACT PUBMED 14530441

About this Structure

Full experimental information is available from OCA.

Reference

Structural study of DNA duplex containing an N-(2-deoxy-beta-D-erythro-pentofuranosyl) formamide frameshift by NMR and restrained molecular dynamics., Maufrais C, Fazakerley GV, Cadet J, Boulard Y, Nucleic Acids Res. 2003 Oct 15;31(20):5930-40. PMID:14530441

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