1osu: Difference between revisions

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[[Image:1osu.jpg|left|200px]]
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[[Image:1osu.png|left|200px]]


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'''STRUCTURE OF THE RNA HEXAMER, R(UUCGCG), WITH A 5'-UU-OVERHANG EXHIBITING HOOGSTEEN-LIKE TRANS U-U BASE PAIRS'''
===STRUCTURE OF THE RNA HEXAMER, R(UUCGCG), WITH A 5'-UU-OVERHANG EXHIBITING HOOGSTEEN-LIKE TRANS U-U BASE PAIRS===




==Overview==
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The crystal structure of the RNA fragment, 5'-r(UUCGCG)-3', has been determined at 1.4 A resolution by a combination of single isomorphous replacement and molecular search methods. The 3'-terminal CGCG portion of the hexamer engages in Watson-Crick hydrogen bonding while the 5'-terminal UU-overhang forms novel Hoogsteen-like U.U self-base pairs with the overhang of an adjacent duplex. The U.U pairs display a single conventional hydrogen bond between O4 (U1) and N3 (U8) and a CH-O hydrogen bond between C5-H (U1) and O4 (U8), through the Hoogsteen face of the pyrimidine base U1. This unusual arrangement of one of the bases results in a trans U.U pair on antiparallel strands in contrast to the usual cis base pairs. The structure emphasizes the pronounced polymorphism of U.U pairs and has implications for folding of RNA molecules.
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{{ABSTRACT_PUBMED_8548450}}


==About this Structure==
==About this Structure==
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[[Category: Mismatched]]
[[Category: Mismatched]]
[[Category: Nicked]]
[[Category: Nicked]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 04:14:31 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:48:52 2008''

Revision as of 15:49, 27 July 2008

File:1osu.png

Template:STRUCTURE 1osu

STRUCTURE OF THE RNA HEXAMER, R(UUCGCG), WITH A 5'-UU-OVERHANG EXHIBITING HOOGSTEEN-LIKE TRANS U-U BASE PAIRS

Template:ABSTRACT PUBMED 8548450

About this Structure

Full crystallographic information is available from OCA.

Reference

The structure of r(UUCGCG) has a 5'-UU-overhang exhibiting Hoogsteen-like trans U.U base pairs., Wahl MC, Rao ST, Sundaralingam M, Nat Struct Biol. 1996 Jan;3(1):24-31. PMID:8548450

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