1otc: Difference between revisions

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[[Image:1otc.~~gif~~|left|200px]]

[[Image:1otc.png|left|200px]]

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~~'''~~THE O. NOVA TELOMERE END BINDING PROTEIN COMPLEXED WITH SINGLE STRAND DNA~~'''~~

===THE O. NOVA TELOMERE END BINDING PROTEIN COMPLEXED WITH SINGLE STRAND DNA===

~~==Overview==~~

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~~Telomeres are specialized protein-DNA complexes that compose~~ the ~~ends of eukaryotic chromosomes. Telomeres protect chromosome termini from degradation and recombination and act together with telomerase~~ to ~~ensure complete genome replication. We have determined~~ the ~~crystal structure of the two-subunit Oxytricha nova telomere end binding protein~~ (~~OnTEBP) complexed with single strand telomeric DNA~~ at 2.~~8 A resolution~~. ~~The structure reveals four oligonucleotide/oligosaccharide-binding folds~~, ~~three of which form a deep cleft that binds~~ the ~~ssDNA, and a fourth that forms an unusual protein~~-~~protein interaction between the alpha and beta subunits. This structure provides a molecular description of how the two subunits of OnTEBP recognize and bind ssDNA to form a sequence~~-~~specific, telomeric nucleoprotein complex that caps the very 3' ends of chromosomes.~~

The line below this paragraph, {{ABSTRACT_PUBMED_9875850}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 9875850 is the PubMed ID number.

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==About this Structure==

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[[Category: Single strand dna binding protein]]

[[Category: Telomere]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 04~~:15:35 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:29:28 2008''

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-[[Image:1otc.gif|left|200px]]
+{{Seed}}
+[[Image:1otc.png|left|200px]]
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 {{STRUCTURE_1otc|  PDB=1otc  |  SCENE=  }}
-'''THE O. NOVA TELOMERE END BINDING PROTEIN COMPLEXED WITH SINGLE STRAND DNA'''
+===THE O. NOVA TELOMERE END BINDING PROTEIN COMPLEXED WITH SINGLE STRAND DNA===
-==Overview==
+<!--
-Telomeres are specialized protein-DNA complexes that compose the ends of eukaryotic chromosomes. Telomeres protect chromosome termini from degradation and recombination and act together with telomerase to ensure complete genome replication. We have determined the crystal structure of the two-subunit Oxytricha nova telomere end binding protein (OnTEBP) complexed with single strand telomeric DNA at 2.8 A resolution. The structure reveals four oligonucleotide/oligosaccharide-binding folds, three of which form a deep cleft that binds the ssDNA, and a fourth that forms an unusual protein-protein interaction between the alpha and beta subunits. This structure provides a molecular description of how the two subunits of OnTEBP recognize and bind ssDNA to form a sequence-specific, telomeric nucleoprotein complex that caps the very 3' ends of chromosomes.
+The line below this paragraph, {{ABSTRACT_PUBMED_9875850}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 9875850 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_9875850}}
 ==About this Structure==
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 [[Category: Single strand dna binding protein]]
 [[Category: Telomere]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 04:15:35 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:29:28 2008''