1ou9: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,615 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,615 edits
No edit summary
Line 1: Line 1:
[[Image:1ou9.jpg|left|200px]]
{{Seed}}
[[Image:1ou9.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1ou9|  PDB=1ou9  |  SCENE=  }}  
{{STRUCTURE_1ou9|  PDB=1ou9  |  SCENE=  }}  


'''Structure of SspB, a AAA+ protease delivery protein'''
===Structure of SspB, a AAA+ protease delivery protein===




==Overview==
<!--
Substrate selection by AAA+ ATPases that function to unfold proteins or alter protein conformation is often regulated by delivery or adaptor proteins. SspB is a protein dimer that binds to the ssrA degradation tag and delivers proteins bearing this tag to ClpXP, an AAA+ protease, for degradation. Here, we describe the structure of the peptide binding domain of H. influenzae SspB in complex with an ssrA peptide at 1.6 A resolution. The ssrA peptides are bound in well-defined clefts located at the extreme ends of the SspB homodimer. SspB contacts residues within the N-terminal and central regions of the 11 residue ssrA tag but leaves the C-terminal residues exposed and positioned to dock with ClpX. This structure, taken together with biochemical analysis of SspB, suggests mechanisms by which proteins like SspB escort substrates to AAA+ ATPases and enhance the specificity and affinity of target recognition.
The line below this paragraph, {{ABSTRACT_PUBMED_14536076}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 14536076 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_14536076}}


==About this Structure==
==About this Structure==
Line 29: Line 33:
[[Category: Homodimer]]
[[Category: Homodimer]]
[[Category: Ssra peptide-binding protein]]
[[Category: Ssra peptide-binding protein]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 04:17:16 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 11:21:10 2008''

Revision as of 08:21, 28 July 2008

File:1ou9.png

Template:STRUCTURE 1ou9

Structure of SspB, a AAA+ protease delivery protein

Template:ABSTRACT PUBMED 14536076

About this Structure

1OU9 is a Single protein structure of sequence from Haemophilus influenzae. Full crystallographic information is available from OCA.

Reference

Structure of a delivery protein for an AAA+ protease in complex with a peptide degradation tag., Levchenko I, Grant RA, Wah DA, Sauer RT, Baker TA, Mol Cell. 2003 Aug;12(2):365-72. PMID:14536076

Page seeded by OCA on Mon Jul 28 11:21:10 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=1ou9&oldid=696074"