1ov3: Difference between revisions

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[[Image:1ov3.~~gif~~|left|200px]]

[[Image:1ov3.png|left|200px]]

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~~'''~~Structure of the p22phox-p47phox complex~~'''~~

===Structure of the p22phox-p47phox complex===

~~==Overview==~~

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The ~~multi-subunit NADPH oxidase complex plays a crucial role in host defense against microbial infection through~~ the ~~production of reactive oxygen species. Activation of the NADPH oxidase requires the targeting of a cytoplasmic p40-p47-p67(phox) complex~~ to the ~~membrane bound heterodimeric p22-gp91~~(~~phox~~) ~~flavocytochrome. This interaction~~ is ~~prevented in~~ the ~~resting state due to an auto-inhibited conformation of p47(phox)~~. ~~The X~~-~~ray structure of the auto~~-inhibited form of p47(phox) reveals that tandem SH3 domains function together to maintain the cytoplasmic complex in an inactive form. Further structural and biochemical data show that phosphorylation of p47(phox) activates a molecular switch that relieves the inhibitory intramolecular interaction. This permits p47(phox) to interact with the cytoplasmic tail of p22(phox) and initiate formation of the active, membrane bound enzyme complex.

The line below this paragraph, {{ABSTRACT_PUBMED_12732142}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 12732142 is the PubMed ID number.

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==Disease==

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[[Category: P22phox]]

[[Category: P47phox]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3~~ 04:18:53 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 04:14:21 2008''

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-[[Image:1ov3.gif|left|200px]]
+{{Seed}}
+[[Image:1ov3.png|left|200px]]
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 {{STRUCTURE_1ov3|  PDB=1ov3  |  SCENE=  }}
-'''Structure of the p22phox-p47phox complex'''
+===Structure of the p22phox-p47phox complex===
-==Overview==
+<!--
-The multi-subunit NADPH oxidase complex plays a crucial role in host defense against microbial infection through the production of reactive oxygen species. Activation of the NADPH oxidase requires the targeting of a cytoplasmic p40-p47-p67(phox) complex to the membrane bound heterodimeric p22-gp91(phox) flavocytochrome. This interaction is prevented in the resting state due to an auto-inhibited conformation of p47(phox). The X-ray structure of the auto-inhibited form of p47(phox) reveals that tandem SH3 domains function together to maintain the cytoplasmic complex in an inactive form. Further structural and biochemical data show that phosphorylation of p47(phox) activates a molecular switch that relieves the inhibitory intramolecular interaction. This permits p47(phox) to interact with the cytoplasmic tail of p22(phox) and initiate formation of the active, membrane bound enzyme complex.
+The line below this paragraph, {{ABSTRACT_PUBMED_12732142}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 12732142 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_12732142}}
 ==Disease==
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 [[Category: P22phox]]
 [[Category: P47phox]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 04:18:53 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 04:14:21 2008''