1ova: Difference between revisions

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[[Image:1ova.gif|left|200px]]
{{Seed}}
[[Image:1ova.png|left|200px]]


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{{STRUCTURE_1ova|  PDB=1ova  |  SCENE=  }}  
{{STRUCTURE_1ova|  PDB=1ova  |  SCENE=  }}  


'''CRYSTAL STRUCTURE OF UNCLEAVED OVALBUMIN AT 1.95 ANGSTROMS RESOLUTION'''
===CRYSTAL STRUCTURE OF UNCLEAVED OVALBUMIN AT 1.95 ANGSTROMS RESOLUTION===




==Overview==
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Ovalbumin, the major protein in avian egg-white, is a non-inhibitory member of the serine protease inhibitor (serpin) superfamily. The crystal structure of uncleaved, hen ovalbumin was solved by the molecular replacement method using the structure of plakalbumin, a proteolytically cleaved form of ovalbumin, as a starting model. The final refined model, including four ovalbumin molecules, 678 water molecules and a single metal ion, has a crystallographic R-factor of 17.4% for all reflections between 6.0 and 1.95 A resolution. The root-mean-square deviation from ideal values in bond lengths is 0.02 A and in bond angles is 2.9 degrees. This is the first crystal structure of a member of the serpin family in an uncleaved form. Surprisingly, the peptide that is homologous to the reactive centre of inhibitory serpins adopts an alpha-helical conformation. The implications for the mechanism of inhibition of the inhibitory members of the family is discussed.
The line below this paragraph, {{ABSTRACT_PUBMED_1942038}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_1942038}}


==About this Structure==
==About this Structure==
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[[Category: Stein, P E.]]
[[Category: Stein, P E.]]
[[Category: Serpin]]
[[Category: Serpin]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 04:19:12 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 02:34:30 2008''

Revision as of 23:34, 27 July 2008

File:1ova.png

Template:STRUCTURE 1ova

CRYSTAL STRUCTURE OF UNCLEAVED OVALBUMIN AT 1.95 ANGSTROMS RESOLUTION

Template:ABSTRACT PUBMED 1942038

About this Structure

1OVA is a Single protein structure of sequence from Gallus gallus. Full crystallographic information is available from OCA.

Reference

Crystal structure of uncleaved ovalbumin at 1.95 A resolution., Stein PE, Leslie AG, Finch JT, Carrell RW, J Mol Biol. 1991 Oct 5;221(3):941-59. PMID:1942038

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