1ox7: Difference between revisions

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[[Image:1ox7.gif|left|200px]]
{{Seed}}
[[Image:1ox7.png|left|200px]]


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{{STRUCTURE_1ox7|  PDB=1ox7  |  SCENE=  }}  
{{STRUCTURE_1ox7|  PDB=1ox7  |  SCENE=  }}  


'''Crystal structure of yeast cytosine deaminase apo-enzyme: inorganic zinc bound'''
===Crystal structure of yeast cytosine deaminase apo-enzyme: inorganic zinc bound===




==Overview==
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Cytosine deaminase (CD) catalyzes the deamination of cytosine and is only present in prokaryotes and fungi, where it is a member of the pyrimidine salvage pathway. The enzyme is of interest both for antimicrobial drug design and gene therapy applications against tumors. The structure of Saccharomyces cerevisiae CD has been determined in the presence and absence of a mechanism-based inhibitor, at 1.14 and 1.43 A resolution, respectively. The enzyme forms an alpha/beta fold similar to bacterial cytidine deaminase, but with no similarity to the alpha/beta barrel fold used by bacterial cytosine deaminase or mammalian adenosine deaminase. The structures observed for bacterial, fungal, and mammalian nucleic acid deaminases represent an example of the parallel evolution of two unique protein folds to carry out the same reaction on a diverse array of substrates.
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{{ABSTRACT_PUBMED_12906827}}


==About this Structure==
==About this Structure==
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[[Category: Stoddard, B L.]]
[[Category: Stoddard, B L.]]
[[Category: Aminohydrolase]]
[[Category: Aminohydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:57:51 2008''

Revision as of 20:57, 27 July 2008

File:1ox7.png

Template:STRUCTURE 1ox7

Crystal structure of yeast cytosine deaminase apo-enzyme: inorganic zinc bound

Template:ABSTRACT PUBMED 12906827

About this Structure

1OX7 is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

The 1.14 A crystal structure of yeast cytosine deaminase: evolution of nucleotide salvage enzymes and implications for genetic chemotherapy., Ireton GC, Black ME, Stoddard BL, Structure. 2003 Aug;11(8):961-72. PMID:12906827

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