1oxa: Difference between revisions

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[[Image:1oxa.jpg|left|200px]]
{{Seed}}
[[Image:1oxa.png|left|200px]]


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{{STRUCTURE_1oxa|  PDB=1oxa  |  SCENE=  }}  
{{STRUCTURE_1oxa|  PDB=1oxa  |  SCENE=  }}  


'''CYTOCHROME P450 (DONOR:O2 OXIDOREDUCTASE)'''
===CYTOCHROME P450 (DONOR:O2 OXIDOREDUCTASE)===




==Overview==
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Cytochrome P450eryF catalyzes the 6S-hydroxylation of 6-deoxyerythronolide B, the initial reaction in a multistep pathway to convert 6-deoxyerythronolide B into the antibiotic, erythromycin. The overall structure of P450eryF is similar to that of P450cam but differs in the exact positioning of several alpha-helices. The largest difference occurs in the B' helix and results in the enlargement of the substrate-binding pocket of P450eryF. The substrate is positioned with the macrolide ring perpendicular to the haem plane and contacts seven hydrophobic residues and three solvent molecules. The substrate participates in a network of hydrogen bonds that may provide a proton shuttle pathway in the oxygen cleavage reaction.
The line below this paragraph, {{ABSTRACT_PUBMED_7749919}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 7749919 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7749919}}


==About this Structure==
==About this Structure==
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[[Category: Cupp-Vickery, J R.]]
[[Category: Cupp-Vickery, J R.]]
[[Category: Poulos, T L.]]
[[Category: Poulos, T L.]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 04:23:26 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 05:13:10 2008''
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