1oy2: Difference between revisions

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[[Image:1oy2.jpg|left|200px]]

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~~'''~~Coupling of Folding and Binding in the PTB Domain of the Signaling Protein Shc~~'''~~

===Coupling of Folding and Binding in the PTB Domain of the Signaling Protein Shc===

~~==Overview==~~

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The ~~notion that certain proteins lack intrinsic globular structure under physiological conditions and that~~ the ~~attainment of fully folded structure only occurs upon~~ the ~~binding of target molecules has been recently gaining popularity~~. ~~We report here the solution structure of the PTB domain of the signaling protein Shc in the free form~~. ~~Comparison of this structure with that of the complex form~~, ~~obtained previously with a phosphopeptide ligand, reveals that the Shc PTB domain~~ is ~~structurally disordered in~~ the free form, particularly around the regions constituting the peptide binding pocket. The binding of the ligand appears to reorganize this pocket through local folding events triggering a conformational switch between the free and the complex forms.

The line below this paragraph, {{ABSTRACT_PUBMED_12906822}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 12906822 is the PubMed ID number.

-->

==About this Structure==

1OY2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OY2 OCA].

1OY2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OY2 OCA].

==Reference==

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[[Category: Free protein]]

[[Category: Structure disorder]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 04~~:25:17 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 18:34:18 2008''

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+{{Seed}}
 [[Image:1oy2.jpg|left|200px]]
@@ Line 9: / Line 10: @@
 {{STRUCTURE_1oy2|  PDB=1oy2  |  SCENE=  }}
-'''Coupling of Folding and Binding in the PTB Domain of the Signaling Protein Shc'''
+===Coupling of Folding and Binding in the PTB Domain of the Signaling Protein Shc===
-==Overview==
+<!--
-The notion that certain proteins lack intrinsic globular structure under physiological conditions and that the attainment of fully folded structure only occurs upon the binding of target molecules has been recently gaining popularity. We report here the solution structure of the PTB domain of the signaling protein Shc in the free form. Comparison of this structure with that of the complex form, obtained previously with a phosphopeptide ligand, reveals that the Shc PTB domain is structurally disordered in the free form, particularly around the regions constituting the peptide binding pocket. The binding of the ligand appears to reorganize this pocket through local folding events triggering a conformational switch between the free and the complex forms.
+The line below this paragraph, {{ABSTRACT_PUBMED_12906822}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 12906822 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_12906822}}
 ==About this Structure==
-OY2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OY2 OCA].
+OY2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OY2 OCA].
 ==Reference==
@@ Line 30: / Line 34: @@
 [[Category: Free protein]]
 [[Category: Structure disorder]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 04:25:17 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 18:34:18 2008''