1oye: Difference between revisions

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[[Image:1oye.~~gif~~|left|200px]]

[[Image:1oye.png|left|200px]]

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~~'''~~Structural Basis of Multiple Binding Capacity of the AcrB multidrug Efflux Pump~~'''~~

===Structural Basis of Multiple Binding Capacity of the AcrB multidrug Efflux Pump===

~~==Overview==~~

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~~Multidrug efflux pumps cause serious problems in cancer chemotherapy and treatment of bacterial infections. Yet high~~-~~resolution structures of ligand transporter complexes have previously been unavailable. We obtained x~~-~~ray crystallographic structures of~~ the ~~trimeric AcrB pump from Escherichia coli with four structurally diverse ligands. The structures show that three molecules of ligands bind simultaneously~~ to the ~~extremely large central cavity of 5000 cubic angstroms, primarily by hydrophobic, aromatic stacking and van der Waals interactions~~. ~~Each ligand uses a slightly different subset of AcrB residues for binding~~. ~~The bound ligand molecules often interact with each other~~, ~~stabilizing~~ the ~~binding~~.

The line below this paragraph, {{ABSTRACT_PUBMED_12738864}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 12738864 is the PubMed ID number.

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==About this Structure==

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[[Category: Zgurskaya, H I.]]

[[Category: Membrane protein]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 04~~:25:54 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 02:55:39 2008''

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-[[Image:1oye.gif|left|200px]]
+{{Seed}}
+[[Image:1oye.png|left|200px]]
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 {{STRUCTURE_1oye|  PDB=1oye  |  SCENE=  }}
-'''Structural Basis of Multiple Binding Capacity of the AcrB multidrug Efflux Pump'''
+===Structural Basis of Multiple Binding Capacity of the AcrB multidrug Efflux Pump===
-==Overview==
+<!--
-Multidrug efflux pumps cause serious problems in cancer chemotherapy and treatment of bacterial infections. Yet high-resolution structures of ligand transporter complexes have previously been unavailable. We obtained x-ray crystallographic structures of the trimeric AcrB pump from Escherichia coli with four structurally diverse ligands. The structures show that three molecules of ligands bind simultaneously to the extremely large central cavity of 5000 cubic angstroms, primarily by hydrophobic, aromatic stacking and van der Waals interactions. Each ligand uses a slightly different subset of AcrB residues for binding. The bound ligand molecules often interact with each other, stabilizing the binding.
+The line below this paragraph, {{ABSTRACT_PUBMED_12738864}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 12738864 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_12738864}}
 ==About this Structure==
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 [[Category: Zgurskaya, H I.]]
 [[Category: Membrane protein]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 04:25:54 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 02:55:39 2008''