1oz2: Difference between revisions

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[[Image:1oz2.jpg|left|200px]]
{{Seed}}
[[Image:1oz2.png|left|200px]]


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{{STRUCTURE_1oz2|  PDB=1oz2  |  SCENE=  }}  
{{STRUCTURE_1oz2|  PDB=1oz2  |  SCENE=  }}  


'''CRYSTAL STRUCTURE OF 3-MBT REPEATS OF LETHAL (3) MALIGNANT BRAIN TUMOR (NATIVE-II) AT 1.55 ANGSTROM'''
===CRYSTAL STRUCTURE OF 3-MBT REPEATS OF LETHAL (3) MALIGNANT BRAIN TUMOR (NATIVE-II) AT 1.55 ANGSTROM===




==Overview==
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We report on the X-ray structure of three 100-amino acid mbt repeats in h-l(3)mbt, a polycomb group protein involved in transcriptional repression, whose gene is located in a region of chromosome 20 associated with hematopoietic malignancies. Interdigitation between the extended arms and cores of the mbt repeats results in a three-leaved propeller-like architecture, containing a central cavity. We have identified one ligand binding pocket per mbt repeat, which accommodates either the morphilino ring of MES or the proline ring of the C-terminal peptide segment, within a cavity lined by aromatic amino acids. Strikingly, phenotypic alterations resulting from point mutations or deletions in the mbt repeats of the related Drosophila SCM protein are clustered in and around the ligand binding pocket.
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{{ABSTRACT_PUBMED_12842041}}


==About this Structure==
==About this Structure==
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[[Category: Three malignant brain tumor repeat]]
[[Category: Three malignant brain tumor repeat]]
[[Category: Transcription repressor]]
[[Category: Transcription repressor]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 04:27:18 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 14:13:43 2008''

Revision as of 11:13, 27 July 2008

File:1oz2.png

Template:STRUCTURE 1oz2

CRYSTAL STRUCTURE OF 3-MBT REPEATS OF LETHAL (3) MALIGNANT BRAIN TUMOR (NATIVE-II) AT 1.55 ANGSTROM

Template:ABSTRACT PUBMED 12842041

About this Structure

1OZ2 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Malignant brain tumor repeats: a three-leaved propeller architecture with ligand/peptide binding pockets., Wang WK, Tereshko V, Boccuni P, MacGrogan D, Nimer SD, Patel DJ, Structure. 2003 Jul;11(7):775-89. PMID:12842041

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