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[[Image:1oz8.gif|left|200px]]
{{Seed}}
[[Image:1oz8.png|left|200px]]


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{{STRUCTURE_1oz8|  PDB=1oz8  |  SCENE=  }}  
{{STRUCTURE_1oz8|  PDB=1oz8  |  SCENE=  }}  


'''Intramolecular higher-order packing of parallel quadruplexes comprising a G:G:G:G tetrad and a G(:A):G(:A):G(:A):G heptad of GGA triplet repeat DNA'''
===Intramolecular higher-order packing of parallel quadruplexes comprising a G:G:G:G tetrad and a G(:A):G(:A):G(:A):G heptad of GGA triplet repeat DNA===




==Overview==
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GGA triplet repeats are widely dispersed throughout eukaryotic genomes and are frequently located within biologically important regions such as gene regulatory regions and recombination hot spot sites. We determined the structure of d(GGA)4 (12-mer) under physiological conditions and founded the formation of an intramolecular parallel quadruplex for the first time. Later, a similar architecture to that of the intramolecular parallel quadruplex was found for a telomere DNA in the crystalline state. Here, we have determined the structure of d(GGA)8 (24-mer) under physiological conditions. Two intramolecular parallel quadruplexes comprising a G:G:G:G tetrad and a G(:A):G(:A):G(:A):G heptad are formed in d(GGA)8. These quadruplexes are packed in a tail-to-tail manner. This is the first demonstration of the intramolecular higher order packing of quadruplexes at atomic resolution. K+ ions, but not Na+ ones, are critically required for the formation of this unique structure. The elucidated structure suggests the mechanisms underlying the biological events related to the GGA triplet repeat. Furthermore, in the light of the structure, the mode of the higher order packing of the telomere DNA is discussed.
The line below this paragraph, {{ABSTRACT_PUBMED_12748183}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 12748183 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12748183}}


==About this Structure==
==About this Structure==
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OZ8 OCA].  
Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OZ8 OCA].  


==Reference==
==Reference==
Intramolecular higher order packing of parallel quadruplexes comprising a G:G:G:G tetrad and a G(:A):G(:A):G(:A):G heptad of GGA triplet repeat DNA., Matsugami A, Okuizumi T, Uesugi S, Katahira M, J Biol Chem. 2003 Jul 25;278(30):28147-53. Epub 2003 May 14. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12748183 12748183]
Intramolecular higher order packing of parallel quadruplexes comprising a G:G:G:G tetrad and a G(:A):G(:A):G(:A):G heptad of GGA triplet repeat DNA., Matsugami A, Okuizumi T, Uesugi S, Katahira M, J Biol Chem. 2003 Jul 25;278(30):28147-53. Epub 2003 May 14. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12748183 12748183]
An intramolecular quadruplex of (GGA)(4) triplet repeat DNA with a G:G:G:G tetrad and a G(:A):G(:A):G(:A):G heptad, and its dimeric interaction., Matsugami A, Ouhashi K, Kanagawa M, Liu H, Kanagawa S, Uesugi S, Katahira M, J Mol Biol. 2001 Oct 19;313(2):255-69. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11800555 11800555]
A dimeric RNA quadruplex architecture comprised of two G:G(:A):G:G(:A) hexads, G:G:G:G tetrads and UUUU loops., Liu H, Matsugami A, Katahira M, Uesugi S, J Mol Biol. 2002 Oct 4;322(5):955-70. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12367521 12367521]
[[Category: Katahira, M.]]
[[Category: Katahira, M.]]
[[Category: Matsugami, A.]]
[[Category: Matsugami, A.]]
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[[Category: Uesugi, S.]]
[[Category: Uesugi, S.]]
[[Category: Intramolecular packing of parallel quadruplex]]
[[Category: Intramolecular packing of parallel quadruplex]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 04:27:43 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 11:42:51 2008''

Revision as of 08:42, 28 July 2008

File:1oz8.png

Template:STRUCTURE 1oz8

Intramolecular higher-order packing of parallel quadruplexes comprising a G:G:G:G tetrad and a G(:A):G(:A):G(:A):G heptad of GGA triplet repeat DNA

Template:ABSTRACT PUBMED 12748183

About this Structure

Full experimental information is available from OCA.

Reference

Intramolecular higher order packing of parallel quadruplexes comprising a G:G:G:G tetrad and a G(:A):G(:A):G(:A):G heptad of GGA triplet repeat DNA., Matsugami A, Okuizumi T, Uesugi S, Katahira M, J Biol Chem. 2003 Jul 25;278(30):28147-53. Epub 2003 May 14. PMID:12748183

An intramolecular quadruplex of (GGA)(4) triplet repeat DNA with a G:G:G:G tetrad and a G(:A):G(:A):G(:A):G heptad, and its dimeric interaction., Matsugami A, Ouhashi K, Kanagawa M, Liu H, Kanagawa S, Uesugi S, Katahira M, J Mol Biol. 2001 Oct 19;313(2):255-69. PMID:11800555

A dimeric RNA quadruplex architecture comprised of two G:G(:A):G:G(:A) hexads, G:G:G:G tetrads and UUUU loops., Liu H, Matsugami A, Katahira M, Uesugi S, J Mol Biol. 2002 Oct 4;322(5):955-70. PMID:12367521

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