1ozy: Difference between revisions

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[[Image:1ozy.jpg|left|200px]]
{{Seed}}
[[Image:1ozy.png|left|200px]]


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{{STRUCTURE_1ozy|  PDB=1ozy  |  SCENE=  }}  
{{STRUCTURE_1ozy|  PDB=1ozy  |  SCENE=  }}  


'''Crystal Structure of Phospholipase A2 (MIPLA3) From Micropechis Ikaheka'''
===Crystal Structure of Phospholipase A2 (MIPLA3) From Micropechis Ikaheka===




==Overview==
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Comparison of the crystal structures of three Micropechis ikaheka phospholipase A2 isoenzymes (MiPLA2, MiPLA3 and MiPLA4, which exhibit different levels of pharmacological effects) shows that their C-terminus (residues 110-124) is the most variable. M-Type receptor binding affinity of the isoenzymes has also been investigated and MiPLA4 binds to the rabbit M-type receptor with high affinity. Examination of surface charges of the isoenzymes reveals a trend of increase in positive charges with potency. The isoenzymes are shown to oligomerize in a concentration-dependent manner in a semi-denaturing gel. The C-termini of the medium (MiPLA4) and highly potent (MiPLA2) isoenzyme molecules cluster together, forming a highly exposed area. A BLAST search using the sequence of the most potent MiPLA2 results in high similarity to Staphylococcus aureus clotting factor A and cadherin 11. This might explain the myotoxicity, anticoagulant and hemoglobinuria effects of MiPLA2s.
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{{ABSTRACT_PUBMED_15720395}}


==About this Structure==
==About this Structure==
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==Reference==
==Reference==
Structure and function comparison of Micropechis ikaheka snake venom phospholipase A2 isoenzymes., Lok SM, Gao R, Rouault M, Lambeau G, Gopalakrishnakone P, Swaminathan K, FEBS J. 2005 Mar;272(5):1211-20. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15720395 15720395]
Structure and function comparison of Micropechis ikaheka snake venom phospholipase A2 isoenzymes., Lok SM, Gao R, Rouault M, Lambeau G, Gopalakrishnakone P, Swaminathan K, FEBS J. 2005 Mar;272(5):1211-20. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15720395 15720395]
Purification and properties of three new phospholipase A2 isoenzymes from Micropechis ikaheka venom., Gao R, Kini RM, Li G, Luo R, Selvanayagam ZE, Gopalakrishnakone P, Biochim Biophys Acta. 2001 Feb 9;1545(1-2):30-40. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11342029 11342029]
[[Category: Lok, S M.]]
[[Category: Lok, S M.]]
[[Category: Swaminathan, K.]]
[[Category: Swaminathan, K.]]
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[[Category: Pancreatic loop]]
[[Category: Pancreatic loop]]
[[Category: Phospholipase a2]]
[[Category: Phospholipase a2]]
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