1p09: Difference between revisions

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[[Image:1p09.~~gif~~|left|200px]]

[[Image:1p09.png|left|200px]]

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~~'''~~STRUCTURAL PLASTICITY AS A DETERMINANT OF ENZYME SPECIFICITY. CREATING BROADLY SPECIFIC PROTEASES~~'''~~

===STRUCTURAL PLASTICITY AS A DETERMINANT OF ENZYME SPECIFICITY. CREATING BROADLY SPECIFIC PROTEASES===

~~==Overview==~~

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The ~~substrate specificity of alpha-lytic protease has been changed dramatically~~, ~~with a concomitant increase in activity~~, ~~by replacing an active-site Met with Ala~~. ~~The substrate specificity of both this mutant and another similar mutant are extraordinarily broad~~. ~~X-ray crystallographic analysis shows that structural plasticity~~, ~~a combination of alternate side~~-~~chain conformations and binding~~-~~site flexibility, allows both large and small substrates to be well accommodated.~~

The line below this paragraph, {{ABSTRACT_PUBMED_2716847}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 2716847 is the PubMed ID number.

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==About this Structure==

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[[Category: Agard, D A.]]

[[Category: Bone, R.]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 04~~:30:45 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 13:35:41 2008''

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-[[Image:1p09.gif|left|200px]]
+{{Seed}}
+[[Image:1p09.png|left|200px]]
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 {{STRUCTURE_1p09|  PDB=1p09  |  SCENE=  }}
-'''STRUCTURAL PLASTICITY AS A DETERMINANT OF ENZYME SPECIFICITY. CREATING BROADLY SPECIFIC PROTEASES'''
+===STRUCTURAL PLASTICITY AS A DETERMINANT OF ENZYME SPECIFICITY. CREATING BROADLY SPECIFIC PROTEASES===
-==Overview==
+<!--
-The substrate specificity of alpha-lytic protease has been changed dramatically, with a concomitant increase in activity, by replacing an active-site Met with Ala. The substrate specificity of both this mutant and another similar mutant are extraordinarily broad. X-ray crystallographic analysis shows that structural plasticity, a combination of alternate side-chain conformations and binding-site flexibility, allows both large and small substrates to be well accommodated.
+The line below this paragraph, {{ABSTRACT_PUBMED_2716847}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 2716847 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_2716847}}
 ==About this Structure==
@@ Line 25: / Line 29: @@
 [[Category: Agard, D A.]]
 [[Category: Bone, R.]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 04:30:45 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 13:35:41 2008''