1p25: Difference between revisions

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[[Image:1p25.gif|left|200px]]
{{Seed}}
[[Image:1p25.png|left|200px]]


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{{STRUCTURE_1p25|  PDB=1p25  |  SCENE=  }}  
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'''Crystal structure of nickel(II)-d(GGCGCC)2'''
===Crystal structure of nickel(II)-d(GGCGCC)2===




==Overview==
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Three novel X-ray crystal structures for the DNA hexamer d(GGCGCC) in the B-form complexed to divalent cobalt, nickel and zinc ions have been determined to a resolution of 2.9-3.0 A. The structures were isomorphous and had five DNA strands and five metal cations per asymmetric unit. In all three cases, divalent metal cations were coordinated only to the terminal guanine residue at the N(7) position, with no metal ions binding to non-terminal guanine positions. Water molecules bound to the metal cations interacted with neighboring guanine residues 3' to the ones to which the cations were coordinated, affecting the propeller twist. Even though DNA occupied only about 35% of the unit cell volume, it is interesting that the few interactions involving the metal cations were sufficient to stabilize the crystal lattice. As well as lending support to the proposal that these metals do not coordinate to B-DNA in a stable manner, the results presented here also extend the crystallographic evidence for this phenomenon to the GGC and CGC sequences for all three metal cations.
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{{ABSTRACT_PUBMED_14505075}}


==About this Structure==
==About this Structure==
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[[Category: B-dna]]
[[Category: B-dna]]
[[Category: Nickel binding]]
[[Category: Nickel binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 07:19:19 2008''

Revision as of 04:19, 28 July 2008

File:1p25.png

Template:STRUCTURE 1p25

Crystal structure of nickel(II)-d(GGCGCC)2

Template:ABSTRACT PUBMED 14505075

About this Structure

Full crystallographic information is available from OCA.

Reference

Cobalt(II), nickel(II) and zinc(II) do not bind to intra-helical N(7) guanine positions in the B-form crystal structure of d(GGCGCC)., Labiuk SL, Delbaere LT, Lee JS, J Biol Inorg Chem. 2003 Sep;8(7):715-20. Epub 2003 Jul 9. PMID:14505075

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