1p4l: Difference between revisions

Line 1:

[[Image:1p4l.~~gif~~|left|200px]]

[[Image:1p4l.png|left|200px]]

<!--

Line 9:

Line 10:

~~'''~~Crystal structure of NK receptor Ly49C mutant with its MHC class I ligand H-2Kb~~'''~~

===Crystal structure of NK receptor Ly49C mutant with its MHC class I ligand H-2Kb===

~~==Overview==~~

<!--

The Ly49 family of natural killer (NK) receptors regulates NK cell function by sensing major histocompatibility complex (MHC) class I. Ly49 receptors show complex patterns of MHC class I cross-reactivity and, in certain cases, ~~peptide selectivity. To investigate whether specificity differences result from topological differences in MHC class I engagement~~, ~~we determined~~ the ~~structure of~~ the ~~peptide-selective receptor Ly49C in complex with H-2K~~(b)~~. The Ly49C homodimer binds two MHC class I molecules in symmetrical way~~, ~~a mode distinct from that of Ly49A, which binds MHC class I asymmetrically. Ly49C does not directly contact~~ the ~~MHC-bound peptide~~. ~~In addition, MHC crosslinking by Ly49C was demonstrated in solution. We propose a dynamic model for Ly49~~-~~MHC class I interactions involving conformational changes in the receptor, whereby variations in Ly49 dimerization mediate different MHC~~-~~binding modes.~~

The line below this paragraph, {{ABSTRACT_PUBMED_14595439}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 14595439 is the PubMed ID number.

-->

==About this Structure==

Line 31:

Line 35:

[[Category: Mhc class i]]

[[Category: Natural killer receptor]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3~~ 04:40:49 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:26:53 2008''

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-[[Image:1p4l.gif|left|200px]]
+{{Seed}}
+[[Image:1p4l.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_1p4l|  PDB=1p4l  |  SCENE=  }}
-'''Crystal structure of NK receptor Ly49C mutant with its MHC class I ligand H-2Kb'''
+===Crystal structure of NK receptor Ly49C mutant with its MHC class I ligand H-2Kb===
-==Overview==
+<!--
-The Ly49 family of natural killer (NK) receptors regulates NK cell function by sensing major histocompatibility complex (MHC) class I. Ly49 receptors show complex patterns of MHC class I cross-reactivity and, in certain cases, peptide selectivity. To investigate whether specificity differences result from topological differences in MHC class I engagement, we determined the structure of the peptide-selective receptor Ly49C in complex with H-2K(b). The Ly49C homodimer binds two MHC class I molecules in symmetrical way, a mode distinct from that of Ly49A, which binds MHC class I asymmetrically. Ly49C does not directly contact the MHC-bound peptide. In addition, MHC crosslinking by Ly49C was demonstrated in solution. We propose a dynamic model for Ly49-MHC class I interactions involving conformational changes in the receptor, whereby variations in Ly49 dimerization mediate different MHC-binding modes.
+The line below this paragraph, {{ABSTRACT_PUBMED_14595439}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 14595439 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_14595439}}
 ==About this Structure==
@@ Line 31: / Line 35: @@
 [[Category: Mhc class i]]
 [[Category: Natural killer receptor]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 04:40:49 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:26:53 2008''