1p5n: Difference between revisions

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[[Image:1p5n.~~gif~~|left|200px]]

[[Image:1p5n.png|left|200px]]

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~~'''~~Solution Structure of HCV IRES Domain IIb~~'''~~

===Solution Structure of HCV IRES Domain IIb===

~~==Overview==~~

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~~Complex RNA structures regulate many biological processes~~, ~~but are often too large for structure determination by NMR methods. The 5' untranslated region (5' UTR) of~~ the ~~hepatitis C viral~~ (~~HCV) RNA genome contains an internal ribosome entry site (IRES) that binds to 40S ribosomal subunits with high affinity and specificity to control translation~~. ~~Domain II of the HCV IRES forms a 25-kDa folded subdomain that may alter ribosome conformation~~. ~~We report here~~ the ~~structure of domain II as determined using an NMR approach that combines short- and long-range structural data~~. ~~Domain II adopts a distorted L~~-~~shape structure, and its overall shape in the free form is markedly similar to its 40S subunit~~-~~bound form; this suggests how domain II may modulate 40S subunit conformation. The results show how NMR can be used for structural analysis of large biological RNAs.~~

The line below this paragraph, {{ABSTRACT_PUBMED_14578934}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 14578934 is the PubMed ID number.

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==About this Structure==

Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P5N OCA].

Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P5N OCA].

==Reference==

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[[Category: Loop e motif]]

[[Category: Ribonucleic acid]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 04~~:42:53 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:23:24 2008''

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-[[Image:1p5n.gif|left|200px]]
+{{Seed}}
+[[Image:1p5n.png|left|200px]]
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 {{STRUCTURE_1p5n|  PDB=1p5n  |  SCENE=  }}
-'''Solution Structure of HCV IRES Domain IIb'''
+===Solution Structure of HCV IRES Domain IIb===
-==Overview==
+<!--
-Complex RNA structures regulate many biological processes, but are often too large for structure determination by NMR methods. The 5' untranslated region (5' UTR) of the hepatitis C viral (HCV) RNA genome contains an internal ribosome entry site (IRES) that binds to 40S ribosomal subunits with high affinity and specificity to control translation. Domain II of the HCV IRES forms a 25-kDa folded subdomain that may alter ribosome conformation. We report here the structure of domain II as determined using an NMR approach that combines short- and long-range structural data. Domain II adopts a distorted L-shape structure, and its overall shape in the free form is markedly similar to its 40S subunit-bound form; this suggests how domain II may modulate 40S subunit conformation. The results show how NMR can be used for structural analysis of large biological RNAs.
+The line below this paragraph, {{ABSTRACT_PUBMED_14578934}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 14578934 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_14578934}}
 ==About this Structure==
-Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P5N OCA].
+Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P5N OCA].
 ==Reference==
@@ Line 29: / Line 33: @@
 [[Category: Loop e motif]]
 [[Category: Ribonucleic acid]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 04:42:53 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:23:24 2008''