1p5v: Difference between revisions

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[[Image:1p5v.~~jpg~~|left|200px]]

[[Image:1p5v.png|left|200px]]

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~~'''~~X-ray structure of the Caf1M:Caf1 chaperone:subunit preassembly complex~~'''~~

===X-ray structure of the Caf1M:Caf1 chaperone:subunit preassembly complex===

~~==Overview==~~

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~~Most gram-negative pathogens express fibrous adhesive virulence organelles that mediate targeting~~ to the ~~sites of infection. The F1 capsular antigen from the plague pathogen Yersinia pestis consists of linear fibers of a single subunit~~ (~~Caf1) and serves~~ as ~~a prototype for nonpilus organelles assembled via the chaperone~~/~~usher pathway. Genetic data together with high-resolution X-ray structures corresponding to snapshots of the assembly process reveal the structural basis of fiber formation~~. ~~Comparison of chaperone bound Caf1 subunit with the subunit in the fiber reveals a novel type of conformational change involving the entire hydrophobic core of the protein~~. ~~The observed conformational change suggests that the chaperone traps a high-energy folding intermediate of Caf1. A model~~ is ~~proposed in which release of~~ the ~~subunit allows folding to be completed, driving fiber formation~~.

The line below this paragraph, {{ABSTRACT_PUBMED_12787500}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 12787500 is the PubMed ID number.

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==About this Structure==

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[[Category: Donor strand exchange]]

[[Category: Protein fiber]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 04~~:43:23 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 21:45:53 2008''

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-[[Image:1p5v.jpg|left|200px]]
+{{Seed}}
+[[Image:1p5v.png|left|200px]]
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 {{STRUCTURE_1p5v|  PDB=1p5v  |  SCENE=  }}
-'''X-ray structure of the Caf1M:Caf1 chaperone:subunit preassembly complex'''
+===X-ray structure of the Caf1M:Caf1 chaperone:subunit preassembly complex===
-==Overview==
+<!--
-Most gram-negative pathogens express fibrous adhesive virulence organelles that mediate targeting to the sites of infection. The F1 capsular antigen from the plague pathogen Yersinia pestis consists of linear fibers of a single subunit (Caf1) and serves as a prototype for nonpilus organelles assembled via the chaperone/usher pathway. Genetic data together with high-resolution X-ray structures corresponding to snapshots of the assembly process reveal the structural basis of fiber formation. Comparison of chaperone bound Caf1 subunit with the subunit in the fiber reveals a novel type of conformational change involving the entire hydrophobic core of the protein. The observed conformational change suggests that the chaperone traps a high-energy folding intermediate of Caf1. A model is proposed in which release of the subunit allows folding to be completed, driving fiber formation.
+The line below this paragraph, {{ABSTRACT_PUBMED_12787500}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 12787500 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_12787500}}
 ==About this Structure==
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 [[Category: Donor strand exchange]]
 [[Category: Protein fiber]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 04:43:23 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 21:45:53 2008''