1p6o: Difference between revisions

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[[Image:1p6o.gif|left|200px]]
{{Seed}}
[[Image:1p6o.png|left|200px]]


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{{STRUCTURE_1p6o|  PDB=1p6o  |  SCENE=  }}  
{{STRUCTURE_1p6o|  PDB=1p6o  |  SCENE=  }}  


'''The crystal structure of yeast cytosine deaminase bound to 4(R)-hydroxyl-3,4-dihydropyrimidine at 1.14 angstroms.'''
===The crystal structure of yeast cytosine deaminase bound to 4(R)-hydroxyl-3,4-dihydropyrimidine at 1.14 angstroms.===




==Overview==
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Cytosine deaminase (CD) catalyzes the deamination of cytosine and is only present in prokaryotes and fungi, where it is a member of the pyrimidine salvage pathway. The enzyme is of interest both for antimicrobial drug design and gene therapy applications against tumors. The structure of Saccharomyces cerevisiae CD has been determined in the presence and absence of a mechanism-based inhibitor, at 1.14 and 1.43 A resolution, respectively. The enzyme forms an alpha/beta fold similar to bacterial cytidine deaminase, but with no similarity to the alpha/beta barrel fold used by bacterial cytosine deaminase or mammalian adenosine deaminase. The structures observed for bacterial, fungal, and mammalian nucleic acid deaminases represent an example of the parallel evolution of two unique protein folds to carry out the same reaction on a diverse array of substrates.
The line below this paragraph, {{ABSTRACT_PUBMED_12906827}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 12906827 is the PubMed ID number.
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{{ABSTRACT_PUBMED_12906827}}


==About this Structure==
==About this Structure==
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[[Category: Hydrolase]]
[[Category: Hydrolase]]
[[Category: Inhibitor bound]]
[[Category: Inhibitor bound]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 04:45:12 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 16:40:17 2008''

Revision as of 13:40, 29 July 2008

File:1p6o.png

Template:STRUCTURE 1p6o

The crystal structure of yeast cytosine deaminase bound to 4(R)-hydroxyl-3,4-dihydropyrimidine at 1.14 angstroms.

Template:ABSTRACT PUBMED 12906827

About this Structure

1P6O is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

The 1.14 A crystal structure of yeast cytosine deaminase: evolution of nucleotide salvage enzymes and implications for genetic chemotherapy., Ireton GC, Black ME, Stoddard BL, Structure. 2003 Aug;11(8):961-72. PMID:12906827

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