1p85: Difference between revisions

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[[Image:1p85.~~gif~~|left|200px]]

[[Image:1p85.png|left|200px]]

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~~'''~~Real space refined coordinates of the 50S subunit fitted into the low resolution cryo-EM map of the EF-G.GTP state of E. coli 70S ribosome~~'''~~

===Real space refined coordinates of the 50S subunit fitted into the low resolution cryo-EM map of the EF-G.GTP state of E. coli 70S ribosome===

~~==Overview==~~

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~~Cryo~~-~~EM density maps showing the 70S ribosome of E. coli in two different functional states related by a ratchet~~-~~like motion were analyzed using real-space refinement. Comparison of the two resulting atomic models shows that~~ the ~~ribosome changes from a compact structure~~ to ~~a looser one, coupled with~~ the ~~rearrangement of many of the proteins~~. ~~Furthermore~~, ~~in contrast to~~ the ~~unchanged inter~~-~~subunit bridges formed wholly by RNA, the bridges involving proteins undergo large conformational changes following the ratchet~~-~~like motion, suggesting an important role of ribosomal proteins in facilitating the dynamics of translation.~~

The line below this paragraph, {{ABSTRACT_PUBMED_12809609}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 12809609 is the PubMed ID number.

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==About this Structure==

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[[Category: Ratchet-like movement]]

[[Category: Real-space refinement]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 04~~:48:08 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 14:44:11 2008''

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-[[Image:1p85.gif|left|200px]]
+{{Seed}}
+[[Image:1p85.png|left|200px]]
 <!--
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 {{STRUCTURE_1p85|  PDB=1p85  |  SCENE=  }}
-'''Real space refined coordinates of the 50S subunit fitted into the low resolution cryo-EM map of the EF-G.GTP state of E. coli 70S ribosome'''
+===Real space refined coordinates of the 50S subunit fitted into the low resolution cryo-EM map of the EF-G.GTP state of E. coli 70S ribosome===
-==Overview==
+<!--
-Cryo-EM density maps showing the 70S ribosome of E. coli in two different functional states related by a ratchet-like motion were analyzed using real-space refinement. Comparison of the two resulting atomic models shows that the ribosome changes from a compact structure to a looser one, coupled with the rearrangement of many of the proteins. Furthermore, in contrast to the unchanged inter-subunit bridges formed wholly by RNA, the bridges involving proteins undergo large conformational changes following the ratchet-like motion, suggesting an important role of ribosomal proteins in facilitating the dynamics of translation.
+The line below this paragraph, {{ABSTRACT_PUBMED_12809609}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 12809609 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_12809609}}
 ==About this Structure==
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 [[Category: Ratchet-like movement]]
 [[Category: Real-space refinement]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 04:48:08 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 14:44:11 2008''