|
|
| Line 1: |
Line 1: |
| [[Image:1p8j.gif|left|200px]] | | {{Seed}} |
| | [[Image:1p8j.png|left|200px]] |
|
| |
|
| <!-- | | <!-- |
| Line 9: |
Line 10: |
| {{STRUCTURE_1p8j| PDB=1p8j | SCENE= }} | | {{STRUCTURE_1p8j| PDB=1p8j | SCENE= }} |
|
| |
|
| '''CRYSTAL STRUCTURE OF THE PROPROTEIN CONVERTASE FURIN'''
| | ===CRYSTAL STRUCTURE OF THE PROPROTEIN CONVERTASE FURIN=== |
|
| |
|
|
| |
|
| ==Overview==
| | <!-- |
| In eukaryotes, many essential secreted proteins and peptide hormones are excised from larger precursors by members of a class of calcium-dependent endoproteinases, the prohormone-proprotein convertases (PCs). Furin, the best-characterized member of the mammalian PC family, has essential functions in embryogenesis and homeostasis but is also implicated in various pathologies such as tumor metastasis, neurodegeneration and various bacterial and viral diseases caused by such pathogens as anthrax and pathogenic Ebola virus strains. Furin cleaves protein precursors with narrow specificity following basic Arg-Xaa-Lys/Arg-Arg-like motifs. The 2.6 A crystal structure of the decanoyl-Arg-Val-Lys-Arg-chloromethylketone (dec-RVKR-cmk)-inhibited mouse furin ectodomain, the first PC structure, reveals an eight-stranded jelly-roll P domain associated with the catalytic domain. Contoured surface loops shape the active site by cleft, thus explaining furin's stringent requirement for arginine at P1 and P4, and lysine at P2 sites by highly charge-complementary pockets. The structure also explains furin's preference for basic residues at P3, P5 and P6 sites. This structure will aid in the rational design of antiviral and antibacterial drugs.
| | The line below this paragraph, {{ABSTRACT_PUBMED_12794637}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 12794637 is the PubMed ID number. |
| | --> |
| | {{ABSTRACT_PUBMED_12794637}} |
|
| |
|
| ==About this Structure== | | ==About this Structure== |
| Line 36: |
Line 40: |
| [[Category: Prohormone convertase]] | | [[Category: Prohormone convertase]] |
| [[Category: Spc1]] | | [[Category: Spc1]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:49:12 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:18:10 2008'' |
