8ifg: Difference between revisions

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'''Unreleased structure'''


The entry 8ifg is ON HOLD  until Paper Publication
==Cryo-EM structure of the Clr6S (Clr6-HDAC) complex from S. pombe==
<StructureSection load='8ifg' size='340' side='right'caption='[[8ifg]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[8ifg]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe_972h- Schizosaccharomyces pombe 972h-]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8IFG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8IFG FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ifg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ifg OCA], [https://pdbe.org/8ifg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ifg RCSB], [https://www.ebi.ac.uk/pdbsum/8ifg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ifg ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PRW1_SCHPO PRW1_SCHPO] Has a role in chromatin assembly and chromosome segregation. Involved in the deacetylation of histones.<ref>PMID:12773392</ref>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The Schizosaccharomyces pombe Clr6S complex, a class I histone deacetylase complex, functions as a zinc-dependent enzyme to remove acetyl groups from lysine residues in histone tails. We report here the cryo-EM structure of Clr6S alone and a cryo-EM map of Clr6S in complex with a nucleosome. The active center, revealed at near-atomic resolution, includes features important for catalysis-A water molecule coordinated by zinc, the likely nucleophile for attack on the acetyl-lysine bond, and a loop that may position the substrate for catalysis. The cryo-EM map in the presence of a nucleosome reveals multiple Clr6S-nucleosome contacts and a high degree of relative motion of Clr6S and the nucleosome. Such flexibility may be attributed to interaction at a site in the flexible histone tail and is likely important for the function of the deacetylase, which acts at multiple sites in other histone tails.


Authors:  
Class I histone deacetylase complex: Structure and functional correlates.,Wang X, Wang Y, Liu S, Zhang Y, Xu K, Ji L, Kornberg RD, Zhang H Proc Natl Acad Sci U S A. 2023 Jul 25;120(30):e2307598120. doi: , 10.1073/pnas.2307598120. Epub 2023 Jul 17. PMID:37459529<ref>PMID:37459529</ref>


Description:  
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
<div class="pdbe-citations 8ifg" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Schizosaccharomyces pombe 972h-]]
[[Category: Ji LT]]
[[Category: Kornberg RD]]
[[Category: Liu SM]]
[[Category: Wang X]]
[[Category: Wang YN]]
[[Category: Xu K]]
[[Category: Zhang HQ]]
[[Category: Zhang Y]]
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