1p8v: Difference between revisions

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[[Image:1p8v.~~jpg~~|left|200px]]

[[Image:1p8v.png|left|200px]]

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~~'''~~CRYSTAL STRUCTURE OF THE COMPLEX OF PLATELET RECEPTOR GPIB-ALPHA AND ALPHA-THROMBIN AT 2.6A~~'''~~

===CRYSTAL STRUCTURE OF THE COMPLEX OF PLATELET RECEPTOR GPIB-ALPHA AND ALPHA-THROMBIN AT 2.6A===

~~==Overview==~~

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Direct interaction between platelet receptor glycoprotein Ibalpha (GpIbalpha) and thrombin is required for platelet aggregation and activation at sites of vascular injury. Abnormal GpIbalpha-thrombin binding is associated with many pathological conditions,~~including occlusive arterial thrombosis and bleeding disorders. The crystal structure of~~ the ~~GpIbalpha-thrombin complex~~ at 2.~~6 angstrom resolution reveals simultaneous interactions of GpIbalpha with exosite I of one thrombin molecule,and with exosite II of a second thrombin molecule~~. ~~In the crystal lattice~~,the ~~periodic arrangement of GpIbalpha~~-~~thrombin complexes mirrors a scaffold that could serve as a driving force for tight platelet adhesion. The details of these interactions reconcile GpIbalpha~~-~~thrombin binding modes that are presently controversial,highlighting two distinct interfaces that are potential targets for development of novel antithrombotic drugs.~~

The line below this paragraph, {{ABSTRACT_PUBMED_12855811}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 12855811 is the PubMed ID number.

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==Disease==

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[[Category: Leucine rich repeat domain]]

[[Category: Platelet glycoprotein receptor]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 04~~:49:52 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:51:12 2008''

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-[[Image:1p8v.jpg|left|200px]]
+{{Seed}}
+[[Image:1p8v.png|left|200px]]
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 {{STRUCTURE_1p8v|  PDB=1p8v  |  SCENE=  }}
-'''CRYSTAL STRUCTURE OF THE COMPLEX OF PLATELET RECEPTOR GPIB-ALPHA AND ALPHA-THROMBIN AT 2.6A'''
+===CRYSTAL STRUCTURE OF THE COMPLEX OF PLATELET RECEPTOR GPIB-ALPHA AND ALPHA-THROMBIN AT 2.6A===
-==Overview==
+<!--
-Direct interaction between platelet receptor glycoprotein Ibalpha (GpIbalpha) and thrombin is required for platelet aggregation and activation at sites of vascular injury. Abnormal GpIbalpha-thrombin binding is associated with many pathological conditions,including occlusive arterial thrombosis and bleeding disorders. The crystal structure of the GpIbalpha-thrombin complex at 2.6 angstrom resolution reveals simultaneous interactions of GpIbalpha with exosite I of one thrombin molecule,and with exosite II of a second thrombin molecule. In the crystal lattice,the periodic arrangement of GpIbalpha-thrombin complexes mirrors a scaffold that could serve as a driving force for tight platelet adhesion. The details of these interactions reconcile GpIbalpha-thrombin binding modes that are presently controversial,highlighting two distinct interfaces that are potential targets for development of novel antithrombotic drugs.
+The line below this paragraph, {{ABSTRACT_PUBMED_12855811}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 12855811 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_12855811}}
 ==Disease==
@@ Line 33: / Line 37: @@
 [[Category: Leucine rich repeat domain]]
 [[Category: Platelet glycoprotein receptor]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 04:49:52 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:51:12 2008''