8xe3: Difference between revisions

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'''Unreleased structure'''


The entry 8xe3 is ON HOLD  until Paper Publication
==norbelladine 4'-O-methyltransferase complexed with Mg and SAH==
 
<StructureSection load='8xe3' size='340' side='right'caption='[[8xe3]], [[Resolution|resolution]] 1.72&Aring;' scene=''>
Authors:  
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8xe3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Narcissus_aff._pseudonarcissus_MK-2014 Narcissus aff. pseudonarcissus MK-2014]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8XE3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8XE3 FirstGlance]. <br>
Description:  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.72&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8xe3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8xe3 OCA], [https://pdbe.org/8xe3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8xe3 RCSB], [https://www.ebi.ac.uk/pdbsum/8xe3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8xe3 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/NOMT_NARAP NOMT_NARAP] 4'-O-methyltransferase converting norbelladine to 4'-O-methylnorbelladine. 4'-O-methylnorbelladine is a precursor to all Amaryllidaceae alkaloids such as galanthamine, lycorine and haemanthamine, and including haemanthamine- and crinamine-type alkaloids, promising anticancer agents. Can use norbelladine, N-methylnorbelladine and dopamine as substrate, but not caffeic acid, vanillin, 3,4-dihydroxybenzaldehyde and tyramine.<ref>PMID:25061748</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Narcissus aff. pseudonarcissus MK-2014]]
[[Category: Morita H]]
[[Category: Nakashima Y]]
[[Category: Saw YYH]]
Retrieved from "https://proteopedia.org/8xe3"