1p9u: Difference between revisions

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[[Image:1p9u.gif|left|200px]]
{{Seed}}
[[Image:1p9u.png|left|200px]]


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{{STRUCTURE_1p9u|  PDB=1p9u  |  SCENE=  }}  
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'''Coronavirus Main Proteinase (3CLpro) Structure: Basis for Design of anti-SARS Drugs'''
===Coronavirus Main Proteinase (3CLpro) Structure: Basis for Design of anti-SARS Drugs===




==Overview==
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A novel coronavirus has been identified as the causative agent of severe acute respiratory syndrome (SARS). The viral main proteinase (Mpro, also called 3CLpro), which controls the activities of the coronavirus replication complex, is an attractive target for therapy. We determined crystal structures for human coronavirus (strain 229E) Mpro and for an inhibitor complex of porcine coronavirus [transmissible gastroenteritis virus (TGEV)] Mpro, and we constructed a homology model for SARS coronavirus (SARS-CoV) Mpro. The structures reveal a remarkable degree of conservation of the substrate-binding sites, which is further supported by recombinant SARS-CoV Mpro-mediated cleavage of a TGEV Mpro substrate. Molecular modeling suggests that available rhinovirus 3Cpro inhibitors may be modified to make them useful for treating SARS.
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{{ABSTRACT_PUBMED_12746549}}


==About this Structure==
==About this Structure==
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[[Category: Sars-cov]]
[[Category: Sars-cov]]
[[Category: Tgev]]
[[Category: Tgev]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 04:51:56 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 21:22:45 2008''

Revision as of 18:22, 27 July 2008

File:1p9u.png

Template:STRUCTURE 1p9u

Coronavirus Main Proteinase (3CLpro) Structure: Basis for Design of anti-SARS Drugs

Template:ABSTRACT PUBMED 12746549

About this Structure

1P9U is a Single protein structure of sequence from Transmissible gastroenteritis virus. Full crystallographic information is available from OCA.

Reference

Coronavirus main proteinase (3CLpro) structure: basis for design of anti-SARS drugs., Anand K, Ziebuhr J, Wadhwani P, Mesters JR, Hilgenfeld R, Science. 2003 Jun 13;300(5626):1763-7. Epub 2003 May 13. PMID:12746549

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