1paf: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
Line 1: Line 1:
[[Image:1paf.gif|left|200px]]
{{Seed}}
[[Image:1paf.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1paf|  PDB=1paf  |  SCENE=  }}  
{{STRUCTURE_1paf|  PDB=1paf  |  SCENE=  }}  


'''THE 2.5 ANGSTROMS STRUCTURE OF POKEWEED ANTIVIRAL PROTEIN'''
===THE 2.5 ANGSTROMS STRUCTURE OF POKEWEED ANTIVIRAL PROTEIN===




==Overview==
<!--
The pokeweed antiviral protein (PAP), isolated from the leaves of Phytolacca americana, is one of a family of plant and bacterial ribosome-inhibiting proteins (RIPs) which act as specific N-glycosidases on rRNA. Here we report the three-dimensional structure of PAP determined to 2.5 A resolution by X-ray crystallography. After 14 rounds of refinement, the R factor is 0.17 for 5.0 to 2.5 A data. The protein is homologous with the A chain of ricin and exhibits a very similar folding pattern. The positions of key active site residues are also similar. We also report the 2.8 A structure of PAP complexed with a substrate analog, formycin 5'-monophosphate. As seen previously in ricin, the formycin ring is stacked between invariant tyrosines 72 and 123. Arg179 bonds to N-3 which is thought to be important in catalysis.
The line below this paragraph, {{ABSTRACT_PUBMED_8411176}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 8411176 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_8411176}}


==About this Structure==
==About this Structure==
Line 28: Line 32:
[[Category: Robertus, J D.]]
[[Category: Robertus, J D.]]
[[Category: Protein synthesis inhibitor]]
[[Category: Protein synthesis inhibitor]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 04:52:54 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:17:54 2008''

Revision as of 16:18, 28 July 2008

File:1paf.png

Template:STRUCTURE 1paf

THE 2.5 ANGSTROMS STRUCTURE OF POKEWEED ANTIVIRAL PROTEIN

Template:ABSTRACT PUBMED 8411176

About this Structure

1PAF is a Single protein structure of sequence from Phytolacca americana. Full crystallographic information is available from OCA.

Reference

The 2.5 A structure of pokeweed antiviral protein., Monzingo AF, Collins EJ, Ernst SR, Irvin JD, Robertus JD, J Mol Biol. 1993 Oct 20;233(4):705-15. PMID:8411176

Page seeded by OCA on Mon Jul 28 19:17:54 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=1paf&oldid=711759"