1pbr: Difference between revisions

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[[Image:1pbr.jpg|left|200px]]
{{Seed}}
[[Image:1pbr.png|left|200px]]


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{{STRUCTURE_1pbr|  PDB=1pbr  |  SCENE=  }}  
{{STRUCTURE_1pbr|  PDB=1pbr  |  SCENE=  }}  


'''STRUCTURE OF 16S RIBOSOMAL RNA, NMR, MINIMIZED AVERAGE STRUCTURE'''
===STRUCTURE OF 16S RIBOSOMAL RNA, NMR, MINIMIZED AVERAGE STRUCTURE===




==Overview==
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Aminoglycoside antibiotics that bind to 30S ribosomal A-site RNA cause misreading of the genetic code and inhibit translocation. The aminoglycoside antibiotic paromomycin binds specifically to an RNA oligonucleotide that contains the 30S subunit A site, and the solution structure of the RNA-paromomycin complex was determined by nuclear magnetic resonance spectroscopy. The antibiotic binds in the major groove of the model A-site RNA within a pocket created by an A-A base pair and a single bulged adenine. Specific interactions occur between aminoglycoside chemical groups important for antibiotic activity and conserved nucleotides in the RNA. The structure explains binding of diverse aminoglycosides to the ribosome, their specific activity against prokaryotic organisms, and various resistance mechanisms, and provides insight into ribosome function.
The line below this paragraph, {{ABSTRACT_PUBMED_8910275}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 8910275 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8910275}}


==About this Structure==
==About this Structure==
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PBR OCA].  
Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PBR OCA].  


==Reference==
==Reference==
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[[Category: Ribosomal rna]]
[[Category: Ribosomal rna]]
[[Category: Rna transcript]]
[[Category: Rna transcript]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 04:54:58 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 06:04:23 2008''

Revision as of 03:04, 29 July 2008

File:1pbr.png

Template:STRUCTURE 1pbr

STRUCTURE OF 16S RIBOSOMAL RNA, NMR, MINIMIZED AVERAGE STRUCTURE

Template:ABSTRACT PUBMED 8910275

About this Structure

Full experimental information is available from OCA.

Reference

Structure of the A site of Escherichia coli 16S ribosomal RNA complexed with an aminoglycoside antibiotic., Fourmy D, Recht MI, Blanchard SC, Puglisi JD, Science. 1996 Nov 22;274(5291):1367-71. PMID:8910275

Page seeded by OCA on Tue Jul 29 06:04:23 2008

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