1pc2: Difference between revisions

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[[Image:1pc2.gif|left|200px]]
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[[Image:1pc2.png|left|200px]]


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{{STRUCTURE_1pc2|  PDB=1pc2  |  SCENE=  }}  
{{STRUCTURE_1pc2|  PDB=1pc2  |  SCENE=  }}  


'''Solution structure of human mitochondria fission protein Fis1'''
===Solution structure of human mitochondria fission protein Fis1===




==Overview==
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Fis1 in yeast localizes to the outer mitochondrial membrane and facilitates mitochondrial fission by forming protein complexes with Dnm1 and Mdv1. Fis1 orthologs exist in higher eukaryotes, suggesting that they are functionally conserved. In the present study, we cloned the human Fis1 ortholog that was predicted in a database, and determined the protein structure using NMR spectroscopy. Following a flexible N-terminal tail, six alpha-helices connected with short loops construct a single core domain. The C-terminal tail containing a transmembrane segment appears to be disordered. In the core domain, each of two sequentially adjacent helices forms a hairpin-like conformation, resulting in a six helix assembly forming a slightly twisted slab similar to that of a tandem array of tetratrico-peptide repeat (TPR) motif folds. Within this TPR-like core domain, no significant sequence similarity to the typical TPR motif is found. The structural analogy to the TPR-containing proteins suggests that Fis1 binds to other proteins at its concave hydrophobic surface. A simple composition of Fis1 comprised of a binding domain and a transmembrane segment indicates that the protein may function as a molecular adaptor on the mitochondrial outer membrane. In HeLa cells, however, increased levels in mitochondria-associated Fis1 did not result in mitochondrial translocation of Drp1, a potential binding partner of Fis1 implicated in the regulation of mitochondrial fission, suggesting that the interaction between Drp1 and Fis1 is regulated.
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{{ABSTRACT_PUBMED_14623186}}


==About this Structure==
==About this Structure==
1PC2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PC2 OCA].  
1PC2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PC2 OCA].  


==Reference==
==Reference==
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[[Category: Fission]]
[[Category: Fission]]
[[Category: Mitochondria]]
[[Category: Mitochondria]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 04:55:28 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:58:43 2008''

Revision as of 18:58, 28 July 2008

File:1pc2.png

Template:STRUCTURE 1pc2

Solution structure of human mitochondria fission protein Fis1

Template:ABSTRACT PUBMED 14623186

About this Structure

1PC2 is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

The solution structure of human mitochondria fission protein Fis1 reveals a novel TPR-like helix bundle., Suzuki M, Jeong SY, Karbowski M, Youle RJ, Tjandra N, J Mol Biol. 2003 Nov 28;334(3):445-58. PMID:14623186

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