1pd2: Difference between revisions

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[[Image:1pd2.gif|left|200px]]
{{Seed}}
[[Image:1pd2.png|left|200px]]


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{{STRUCTURE_1pd2|  PDB=1pd2  |  SCENE=  }}  
{{STRUCTURE_1pd2|  PDB=1pd2  |  SCENE=  }}  


'''CRYSTAL STRUCTURE OF HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE COMPLEX WITH GLUTATHIONE'''
===CRYSTAL STRUCTURE OF HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE COMPLEX WITH GLUTATHIONE===




==Overview==
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Hematopoietic prostaglandin (PG) D synthase is the key enzyme for production of the D and J series of prostanoids in the immune system and mast cells. We isolated a cDNA for the rat enzyme, crystallized the recombinant enzyme, and determined the three-dimensional structure of the enzyme complexed with glutathione at 2.3 A resolution. The enzyme is the first member of the sigma class glutathione S-transferase (GST) from vertebrates and possesses a prominent cleft as the active site, which is never seen among other members of the GST family. The unique 3-D architecture of the cleft leads to the putative substrate binding mode and its catalytic mechanism, responsible for the specific isomerization from PGH2 to PGD2.
The line below this paragraph, {{ABSTRACT_PUBMED_9323136}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 9323136 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9323136}}


==About this Structure==
==About this Structure==
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[[Category: Pgd]]
[[Category: Pgd]]
[[Category: Sigma-class gst]]
[[Category: Sigma-class gst]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 04:57:14 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:19:32 2008''
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