1pex: Difference between revisions

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[[Image:1pex.gif|left|200px]]
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[[Image:1pex.png|left|200px]]


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{{STRUCTURE_1pex|  PDB=1pex  |  SCENE=  }}  
{{STRUCTURE_1pex|  PDB=1pex  |  SCENE=  }}  


'''COLLAGENASE-3 (MMP-13) C-TERMINAL HEMOPEXIN-LIKE DOMAIN'''
===COLLAGENASE-3 (MMP-13) C-TERMINAL HEMOPEXIN-LIKE DOMAIN===




==Overview==
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Collagenase-3 (MMP-13) is a matrix metalloproteinase involved in human breast cancer pathology and in arthritic processes. The crystal structure of its C-terminal haemopexin-like domain has been solved by molecular replacement and refined to an R-value of 0.195 using data to 2.7 A resolution. This structure reveals a disk-like shape. The chain is folded into a beta-propeller structure of pseudo 4-fold symmetry, with the four propeller blades arranged around a funnel-like tunnel. This central tunnel tube harbours four ions assigned as two calcium and two chloride ions. The C-terminal domain of collagenase-3 has a similar structure to the equivalent domain of gelatinase A and fibroblast collagenase 1; however, its detailed structure and surface charge pattern has a somewhat greater similarity to the latter, in agreement with the subgrouping of MMP-13 with the collagenase subfamily of MMPs. It is proposed that several small structural differences may act together to confer the characteristic binding and cleavage specificities of collagenases for triple-helical substrates, probably in co-operation with a fitting interdomain linker.
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==About this Structure==
==About this Structure==
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[[Category: Murphy, G.]]
[[Category: Murphy, G.]]
[[Category: C-terminal hemopexin-like domain of matrix-metalloproteinase]]
[[Category: C-terminal hemopexin-like domain of matrix-metalloproteinase]]
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Revision as of 19:22, 27 July 2008

File:1pex.png

Template:STRUCTURE 1pex

COLLAGENASE-3 (MMP-13) C-TERMINAL HEMOPEXIN-LIKE DOMAIN

Template:ABSTRACT PUBMED 8969305

About this Structure

1PEX is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The helping hand of collagenase-3 (MMP-13): 2.7 A crystal structure of its C-terminal haemopexin-like domain., Gomis-Ruth FX, Gohlke U, Betz M, Knauper V, Murphy G, Lopez-Otin C, Bode W, J Mol Biol. 1996 Dec 6;264(3):556-66. PMID:8969305

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