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| [[Image:1pfb.gif|left|200px]] | | {{Seed}} |
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| {{STRUCTURE_1pfb| PDB=1pfb | SCENE= }} | | {{STRUCTURE_1pfb| PDB=1pfb | SCENE= }} |
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| '''Structural Basis for specific binding of polycomb chromodomain to histone H3 methylated at K27'''
| | ===Structural Basis for specific binding of polycomb chromodomain to histone H3 methylated at K27=== |
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| ==Overview==
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| The chromodomain of Drosophila Polycomb protein is essential for maintaining the silencing state of homeotic genes during development. Recent studies suggest that Polycomb mediates the assembly of repressive higher-order chromatin structures in conjunction with the methylation of Lys 27 of histone H3 by a Polycomb group repressor complex. A similar mechanism in heterochromatin assembly is mediated by HP1, a chromodomain protein that binds to histone H3 methylated at Lys 9. To understand the molecular mechanism of the methyl-Lys 27 histone code recognition, we have determined a 1.4-A-resolution structure of the chromodomain of Polycomb in complex with a histone H3 peptide trimethylated at Lys 27. The structure reveals a conserved mode of methyl-lysine binding and identifies Polycomb-specific interactions with histone H3. The structure also reveals a dPC dimer in the crystal lattice that is mediated by residues specifically conserved in the Polycomb family of chromodomains. The dimerization of dPC can effectively account for the histone-binding specificity and provides new mechanistic insights into the function of Polycomb. We propose that self-association is functionally important for Polycomb. | | The line below this paragraph, {{ABSTRACT_PUBMED_12897052}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 12897052 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_12897052}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Histone methylation]] | | [[Category: Histone methylation]] |
| [[Category: Polycomb]] | | [[Category: Polycomb]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:01:02 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:41:16 2008'' |
