1pfz: Difference between revisions

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[[Image:1pfz.gif|left|200px]]
{{Seed}}
[[Image:1pfz.png|left|200px]]


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{{STRUCTURE_1pfz|  PDB=1pfz  |  SCENE=  }}  
{{STRUCTURE_1pfz|  PDB=1pfz  |  SCENE=  }}  


'''PROPLASMEPSIN II FROM PLASMODIUM FALCIPARUM'''
===PROPLASMEPSIN II FROM PLASMODIUM FALCIPARUM===




==Overview==
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Proplasmepsin II is the zymogen of plasmepsin II, an aspartic proteinase used by Plasmodiumfalciparum to digest hemoglobin during the blood stage of malaria. A large shift between the N-domain and the central and C-domains of proplasmepsin II opens the active site cleft, preventing the formation of a functional aspartic proteinase active site. This mode of inhibition of catalytic activity has not been observed in any other aspartic proteinase zymogen. Instead of occluding a pre-formed active site, as in the gastric aspartic proteinase zymogens, the prosegment of proplasmepsin II interacts extensively with the C-domain and serves as a 'harness' to keep the domains apart. Disruption of key salt bridges at low pH may be important in activation.
The line below this paragraph, {{ABSTRACT_PUBMED_9886289}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 9886289 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9886289}}


==About this Structure==
==About this Structure==
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[[Category: Hydrolase]]
[[Category: Hydrolase]]
[[Category: Malaria]]
[[Category: Malaria]]
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