1ph0: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
Line 1: Line 1:
[[Image:1ph0.jpg|left|200px]]
{{Seed}}
[[Image:1ph0.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1ph0|  PDB=1ph0  |  SCENE=  }}  
{{STRUCTURE_1ph0|  PDB=1ph0  |  SCENE=  }}  


'''Non-carboxylic Acid-Containing Inhibitor of PTP1B Targeting the Second Phosphotyrosine Site'''
===Non-carboxylic Acid-Containing Inhibitor of PTP1B Targeting the Second Phosphotyrosine Site===




==Overview==
<!--
Protein tyrosine phosphatase (PTPase) 1B (PTP1B) has been implicated as a key negative regulator of both insulin and leptin signaling cascades. We identified several salicylic acid-based ligands for the second phosphotyrosine binding site of PTP1B using a NMR-based screening. Structure-based linking with a catalytic site-directed oxalylarylaminobenzoic acid-based pharmacophore led to the identification of a novel series of potent PTP1B inhibitors exhibiting 6-fold selectivity over the highly homologous T-cell PTPase (TCPTP) and high selectivity over other phosphatases.
The line below this paragraph, {{ABSTRACT_PUBMED_12877578}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 12877578 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_12877578}}


==About this Structure==
==About this Structure==
Line 36: Line 40:
[[Category: Protein tyrosine phosphatase 1b]]
[[Category: Protein tyrosine phosphatase 1b]]
[[Category: Salicylic acid moiety at the second site]]
[[Category: Salicylic acid moiety at the second site]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 05:04:34 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 16:59:49 2008''
Retrieved from "https://proteopedia.org/1ph0"