1r55: Difference between revisions
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'''Crystal structure of the catalytic domain of human ADAM 33'''<br /> | '''Crystal structure of the catalytic domain of human ADAM 33'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
1R55 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with ZN, CA, CL and 097 as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | 1R55 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene>, <scene name='pdbligand=CA:'>CA</scene>, <scene name='pdbligand=CL:'>CL</scene> and <scene name='pdbligand=097:'>097</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R55 OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: metalloprotease]] | [[Category: metalloprotease]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:47:00 2008'' | ||
Revision as of 14:47, 15 February 2008
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Crystal structure of the catalytic domain of human ADAM 33
Overview
Adam33 is a putative asthma susceptibility gene encoding for a, membrane-anchored metalloprotease belonging to the ADAM family. The ADAMs, (a disintegrin and metalloprotease) are a family of glycoproteins, implicated in cell-cell interactions, cell fusion, and cell signaling. We, have determined the crystal structure of the Adam33 catalytic domain in, complex with the inhibitor marimastat and the inhibitor-free form. The, structures reveal the polypeptide fold and active site environment, resembling that of other metalloproteases. The substrate-binding site, contains unique features that allow the structure-based design of specific, inhibitors of this enzyme.
About this Structure
1R55 is a Single protein structure of sequence from Homo sapiens with ZN, CA, CL and 097 as ligands. Full crystallographic information is available from OCA.
Reference
Crystal structure of the catalytic domain of human ADAM33., Orth P, Reichert P, Wang W, Prosise WW, Yarosh-Tomaine T, Hammond G, Ingram RN, Xiao L, Mirza UA, Zou J, Strickland C, Taremi SS, Le HV, Madison V, J Mol Biol. 2004 Jan 2;335(1):129-37. PMID:14659745
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