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[[Image:1pid.gif|left|200px]]
{{Seed}}
[[Image:1pid.png|left|200px]]


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{{STRUCTURE_1pid|  PDB=1pid  |  SCENE=  }}  
{{STRUCTURE_1pid|  PDB=1pid  |  SCENE=  }}  


'''BOVINE DESPENTAPEPTIDE INSULIN'''
===BOVINE DESPENTAPEPTIDE INSULIN===




==Overview==
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The crystal structure of despentapeptide insulin, a monomeric insulin, has been refined at 1.3 A spacing and subsequently used to predict and model the organization in the insulin fibril. The model makes use of the contacts in the densely packed despentapeptide insulin crystal, and takes into account other experimental evidence, including binding studies with Congo red. The dimensions of this model fibril correspond well with those measured experimentally, and the monomer-monomer contacts within the fibril are in accordance with the known physical chemistry of insulin fibrils. Using this model, it may be possible to predict mutations in insulin that might alleviate problems associated with fibril formation during insulin therapy.
The line below this paragraph, {{ABSTRACT_PUBMED_9141131}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 9141131 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9141131}}


==About this Structure==
==About this Structure==
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[[Category: Glucose metabolism]]
[[Category: Glucose metabolism]]
[[Category: Hormone]]
[[Category: Hormone]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 05:06:57 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 13:47:33 2008''

Revision as of 10:47, 27 July 2008

File:1pid.png

Template:STRUCTURE 1pid

BOVINE DESPENTAPEPTIDE INSULIN

Template:ABSTRACT PUBMED 9141131

About this Structure

1PID is a Protein complex structure of sequences from Bos taurus. Full crystallographic information is available from OCA.

Reference

A model of insulin fibrils derived from the x-ray crystal structure of a monomeric insulin (despentapeptide insulin)., Brange J, Dodson GG, Edwards DJ, Holden PH, Whittingham JL, Proteins. 1997 Apr;27(4):507-16. PMID:9141131

Page seeded by OCA on Sun Jul 27 13:47:33 2008

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