Calcipotriol: Difference between revisions
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<StructureSection load='' size='340' side='right' caption='Caption for this structure' scene='10/1023614/Cv/1'> | <StructureSection load='' size='340' side='right' caption='Caption for this structure' scene='10/1023614/Cv/1'> | ||
Calcipotriol, also known as calcipotriene, is a synthetic derivative of calcitriol, a form of [[Secosteroids|vitamin D]]. It is used in the treatment of psoriasis. It is safe for long-term application in psoriatic skin conditions. See also [https://en.wikipedia.org/wiki/Calcipotriol Calcipotriol] and [[Vitamin D receptor]] (also called calcitriol receptor). | Calcipotriol, also known as calcipotriene, is a synthetic derivative of [[calcitriol]], a form of [[Secosteroids|vitamin D]]. It is used in the treatment of psoriasis. It is safe for long-term application in psoriatic skin conditions. See also [https://en.wikipedia.org/wiki/Calcipotriol Calcipotriol] and [[Vitamin D receptor]] (also called calcitriol receptor). | ||
The precise mechanism of calcipotriol in remitting psoriasis is not well understood. However, it has been shown to have comparable affinity with calcitriol for the [[vitamin D receptor]] (VDR), while being less than 1% as active as the calcitriol in regulating calcium metabolism. The vitamin D receptor belongs to the steroid/thyroid receptor superfamily, and is found on the cells of many different tissues including the thyroid, bone, kidney, and T cells of the immune system. T cells are known to play a role in psoriasis, and it is thought that the binding of calcipotriol to the VDR modulates the T cells gene transcription of cell differentiation and proliferation related genes. | The precise mechanism of calcipotriol in remitting psoriasis is not well understood. However, it has been shown to have comparable affinity with calcitriol for the [[vitamin D receptor]] (VDR), while being less than 1% as active as the calcitriol in regulating calcium metabolism. The vitamin D receptor belongs to the steroid/thyroid receptor superfamily, and is found on the cells of many different tissues including the thyroid, bone, kidney, and T cells of the immune system. T cells are known to play a role in psoriasis, and it is thought that the binding of calcipotriol to the VDR modulates the T cells gene transcription of cell differentiation and proliferation related genes. | ||
