1pob: Difference between revisions

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[[Image:1pob.gif|left|200px]]
{{Seed}}
[[Image:1pob.png|left|200px]]


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{{STRUCTURE_1pob|  PDB=1pob  |  SCENE=  }}  
{{STRUCTURE_1pob|  PDB=1pob  |  SCENE=  }}  


'''CRYSTAL STRUCTURE OF COBRA-VENOM PHOSPHOLIPASE A2 IN A COMPLEX WITH A TRANSITION-STATE ANALOGUE'''
===CRYSTAL STRUCTURE OF COBRA-VENOM PHOSPHOLIPASE A2 IN A COMPLEX WITH A TRANSITION-STATE ANALOGUE===




==Overview==
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The crystal structure of a complex between a phosphonate transition-state analogue and the phospholipase A2 (PLA2) from Naja naja atra venom has been solved and refined to a resolution of 2.0 angstroms. The identical stereochemistry of the two complexes that comprise the crystal's asymmetric unit indicates both the manner in which the transition state is stabilized and how the hydrophobic fatty acyl chains of the substrate are accommodated by the enzyme during interfacial catalysis. The critical features that suggest the chemistry of binding and catalysis are the same as those seen in the crystal structure of a similar complex formed with the evolutionarily distant bee-venom PLA2.
The line below this paragraph, {{ABSTRACT_PUBMED_2274787}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 2274787 is the PubMed ID number.
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{{ABSTRACT_PUBMED_2274787}}


==About this Structure==
==About this Structure==
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[[Category: White, S P.]]
[[Category: White, S P.]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 05:18:18 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:23:19 2008''

Revision as of 21:23, 27 July 2008

File:1pob.png

Template:STRUCTURE 1pob

CRYSTAL STRUCTURE OF COBRA-VENOM PHOSPHOLIPASE A2 IN A COMPLEX WITH A TRANSITION-STATE ANALOGUE

Template:ABSTRACT PUBMED 2274787

About this Structure

1POB is a Single protein structure of sequence from Naja atra. Full crystallographic information is available from OCA.

Reference

Crystal structure of cobra-venom phospholipase A2 in a complex with a transition-state analogue., White SP, Scott DL, Otwinowski Z, Gelb MH, Sigler PB, Science. 1990 Dec 14;250(4987):1560-3. PMID:2274787

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