1pp5: Difference between revisions

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[[Image:1pp5.~~gif~~|left|200px]]

[[Image:1pp5.png|left|200px]]

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~~'''~~Structure of Antibacterial Peptide Microcin J25: a 21-Residue Lariat Protoknot~~'''~~

===Structure of Antibacterial Peptide Microcin J25: a 21-Residue Lariat Protoknot===

~~==Overview==~~

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The ~~antibacterial peptide microcin J25 (MccJ25) inhibits bacterial transcription by binding within~~, ~~and obstructing~~, the ~~nucleotide-uptake channel of bacterial RNA polymerase~~. ~~Published covalent and three-dimensional structures indicate that MccJ25 is a 21-residue cycle~~. ~~Here~~, ~~we show that the published covalent and three-dimensional structures are incorrect, and that MccJ25 in fact~~ is ~~a 21-residue "lariat protoknot", consisting of an 8-residue cyclic segment followed by a 13-residue linear segment that loops back and threads through~~ the ~~cyclic segment~~. ~~MccJ25 is the first example of a lariat protoknot involving a backbone~~-~~side chain amide linkage.~~

The line below this paragraph, {{ABSTRACT_PUBMED_14531661}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 14531661 is the PubMed ID number.

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==About this Structure==

1PP5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PP5 OCA].

1PP5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PP5 OCA].

==Reference==

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[[Category: Psi]]

[[Category: Structural genomic]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 05~~:19:38 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 12:45:03 2008''

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-[[Image:1pp5.gif|left|200px]]
+{{Seed}}
+[[Image:1pp5.png|left|200px]]
 <!--
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 {{STRUCTURE_1pp5|  PDB=1pp5  |  SCENE=  }}
-'''Structure of Antibacterial Peptide Microcin J25: a 21-Residue Lariat Protoknot'''
+===Structure of Antibacterial Peptide Microcin J25: a 21-Residue Lariat Protoknot===
-==Overview==
+<!--
-The antibacterial peptide microcin J25 (MccJ25) inhibits bacterial transcription by binding within, and obstructing, the nucleotide-uptake channel of bacterial RNA polymerase. Published covalent and three-dimensional structures indicate that MccJ25 is a 21-residue cycle. Here, we show that the published covalent and three-dimensional structures are incorrect, and that MccJ25 in fact is a 21-residue "lariat protoknot", consisting of an 8-residue cyclic segment followed by a 13-residue linear segment that loops back and threads through the cyclic segment. MccJ25 is the first example of a lariat protoknot involving a backbone-side chain amide linkage.
+The line below this paragraph, {{ABSTRACT_PUBMED_14531661}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 14531661 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_14531661}}
 ==About this Structure==
-PP5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PP5 OCA].
+PP5 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PP5 OCA].
 ==Reference==
@@ Line 38: / Line 42: @@
 [[Category: Psi]]
 [[Category: Structural genomic]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 05:19:38 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 12:45:03 2008''