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| {{STRUCTURE_1pq3| PDB=1pq3 | SCENE= }} | | {{STRUCTURE_1pq3| PDB=1pq3 | SCENE= }} |
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| '''Human Arginase II: Crystal Structure and Physiological Role in Male and Female Sexual Arousal'''
| | ===Human Arginase II: Crystal Structure and Physiological Role in Male and Female Sexual Arousal=== |
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| ==Overview==
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| Arginase is a binuclear manganese metalloenzyme that catalyzes the hydrolysis of l-arginine to form l-ornithine and urea. The X-ray crystal structure of a fully active, truncated form of human arginase II complexed with a boronic acid transition state analogue inhibitor has been determined at 2.7 A resolution. This structure is consistent with the hydrolysis of l-arginine through a metal-activated hydroxide mechanism. Given that human arginase II appears to play a role in regulating l-arginine bioavailability to NO synthase in human penile corpus cavernosum smooth muscle, the inhibition of human arginase II is a potential new strategy for the treatment of erectile dysfunction [Kim, N. N., Cox, J. D., Baggio, R. F., Emig, F. A., Mistry, S., Harper, S. L., Speicher, D. W., Morris, S. M., Ash, D. E., Traish, A. M., and Christianson, D. W. (2001) Biochemistry 40, 2678-2688]. Since NO synthase is found in human clitoral corpus cavernosum and vagina, we hypothesized that human arginase II is similarly present in these tissues and functions to regulate l-arginine bioavailability to NO synthase. Accordingly, hemodynamic studies conducted with a boronic acid arginase inhibitor in vivo are summarized, suggesting that the extrahepatic arginase plays a role in both male and female sexual arousal. Therefore, arginase II is a potential target for the treatment of male and female sexual arousal disorders.
| | The line below this paragraph, {{ABSTRACT_PUBMED_12859189}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 12859189 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_12859189}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Traish, A M.]] | | [[Category: Traish, A M.]] |
| [[Category: Biosynthetic protein]] | | [[Category: Biosynthetic protein]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 05:21:29 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:14:19 2008'' |
