1pq9: Difference between revisions

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[[Image:1pq9.~~gif~~|left|200px]]

[[Image:1pq9.png|left|200px]]

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~~'''~~HUMAN LXR BETA HORMONE RECEPTOR COMPLEXED WITH T0901317 COMPLEX~~'''~~

===HUMAN LXR BETA HORMONE RECEPTOR COMPLEXED WITH T0901317 COMPLEX===

~~==Overview==~~

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The ~~structures of the liver X receptor LXRbeta (NR1H2) have been determined in complexes with two synthetic ligands~~, ~~T0901317 and GW3965~~, to ~~2.1 and 2.4 A, respectively. Together with its isoform LXRalpha~~ (~~NR1H3)~~ it ~~regulates target genes involved in metabolism and transport of cholesterol and fatty acids~~. ~~The two LXRbeta structures reveal a flexible ligand-binding pocket that can adjust to accommodate fundamentally different ligands~~. ~~The ligand-binding pocket~~ is ~~hydrophobic but with polar or charged residues at~~ the ~~two ends of the cavity~~. ~~T0901317 takes advantage of this by binding to His~~-~~435 close to H12 while GW3965 orients itself with its charged group in the opposite direction. Both ligands induce a fixed "agonist conformation" of helix H12 (also called the AF~~-~~2 domain), resulting in a transcriptionally active receptor.~~

The line below this paragraph, {{ABSTRACT_PUBMED_12819202}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 12819202 is the PubMed ID number.

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==About this Structure==

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[[Category: Wilhelmsson, A.]]

[[Category: Lxrb+t0901317 split]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sat May 3 05~~:21:50 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:38:18 2008''

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-[[Image:1pq9.gif|left|200px]]
+{{Seed}}
+[[Image:1pq9.png|left|200px]]
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 {{STRUCTURE_1pq9|  PDB=1pq9  |  SCENE=  }}
-'''HUMAN LXR BETA HORMONE RECEPTOR COMPLEXED WITH T0901317 COMPLEX'''
+===HUMAN LXR BETA HORMONE RECEPTOR COMPLEXED WITH T0901317 COMPLEX===
-==Overview==
+<!--
-The structures of the liver X receptor LXRbeta (NR1H2) have been determined in complexes with two synthetic ligands, T0901317 and GW3965, to 2.1 and 2.4 A, respectively. Together with its isoform LXRalpha (NR1H3) it regulates target genes involved in metabolism and transport of cholesterol and fatty acids. The two LXRbeta structures reveal a flexible ligand-binding pocket that can adjust to accommodate fundamentally different ligands. The ligand-binding pocket is hydrophobic but with polar or charged residues at the two ends of the cavity. T0901317 takes advantage of this by binding to His-435 close to H12 while GW3965 orients itself with its charged group in the opposite direction. Both ligands induce a fixed "agonist conformation" of helix H12 (also called the AF-2 domain), resulting in a transcriptionally active receptor.
+The line below this paragraph, {{ABSTRACT_PUBMED_12819202}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 12819202 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_12819202}}
 ==About this Structure==
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 [[Category: Wilhelmsson, A.]]
 [[Category: Lxrb+t0901317 split]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 05:21:50 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:38:18 2008''